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Literature summary for 2.4.3.1 extracted from

  • Han, Y.; Zhang, L.; Yu, X.; Wang, S.; Xu, C.; Yin, H.; Wang, S.
    Alginate oligosaccharide attenuates alpha2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway (2019), Cell Death Dis., 10, 374 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R Homo sapiens
-
 CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15907
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
prostate gland cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
-
 Homo sapiens CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
-
 ?

Synonyms

Synonyms Comment Organism
beta-galactoside alpha2,6-sialyltransferase 1
-
 Homo sapiens
ST6Gal-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens alginate oligosaccharide inhibits the expressions of the enzyme both in mRNA levels and protein levels down

General Information

General Information Comment Organism
physiological function the enzyme plays a fundamental role in growth, migration, and invasion of prostate cancer cells. Enzyme overexpression rescues the activation of the Hippo/YAP signaling pathway in prostate cancer cells Homo sapiens