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Literature summary for 2.4.3.1 extracted from

  • Luley-Goedl, C.; Schmoelzer, K.; Thomann, M.; Malik, S.; Greif, M.; Ribitsch, D.; Jung, C.; Sobek, H.; Engel, A.; Mueller, R.; Schwab, H.; Nidetzky, B.
    Two N-terminally truncated variants of human beta-galactoside alpha2,6 sialyltransferase I with distinct properties for invitro protein glycosylation (2016), Glycobiology, 26, 1097-1106.
    View publication on PubMed
Search for more literature for 2.4.3.1

Cloned(Commentary)

Cloned (Comment) Organism
the truncated DELTA89 and DELTA108 variants of the recombinant human enzyme are expressed in human embryonic kidney cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the DELTA108 mutant enzyme shows only sialyl transferase activity with specificity for mono-sialylation and a Km value for 6'-sialyl-N-acetyl-D-lactosamine of 84 mM while the DELTA89 mutant show a Km value for 6'-sialyl-N-acetyl-D-lactosamine of 8.3 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15907
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + 6'-sialyl-N-acetyl-D-lactosamine
-
 Homo sapiens ?
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
beta-galactoside alpha2,6 sialyltransferase I
-
 Homo sapiens
ST6Gal-I
-
 Homo sapiens