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Literature summary for 2.4.3.1 extracted from

  • Liu, Z.; Swindall, A.F.; Kesterson, R.A.; Schoeb, T.R.; Bullard, D.C.; Bellis, S.L.
    ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor (2011), J. Biol. Chem., 286, 39654-39662.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.3.1

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Homo sapiens
50000
-
 x * 50000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1 Homo sapiens
-
 CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1 Mus musculus
-
 CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15907
-
-
Mus musculus Q64685
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
monocyte
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
-
 Homo sapiens CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
-
 Mus musculus CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens
? x * 50000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
beta-galactoside alpha2-6-sialyltransferase-1
-
 Homo sapiens
beta-galactoside alpha2-6-sialyltransferase-1
-
 Mus musculus
ST6Gal-I
-
 Homo sapiens
ST6Gal-I
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme down-regulation limits monocyte/macrophage lifespan by sensitizing cells to apoptosis via tumor necrosis factor receptor I hyposialylation Homo sapiens
malfunction enzyme down-regulation limits monocyte/macrophage lifespan by sensitizing cells to apoptosis via tumor necrosis factor receptor I hyposialylation Mus musculus
physiological function the enzyme regulates macrophage tumor necrosis factor alpha-induced apoptosis via alpha2-6 sialylation of the tumor necrosis factor receptor I death receptor. The enzyme inhibits phorbol-12-myristate-13-acetate-induced suppression of cell growth Homo sapiens
physiological function the enzyme regulates macrophage tumor necrosis factor alpha-induced apoptosis via alpha2-6 sialylation of the tumor necrosis factor receptor I death receptor. The enzyme inhibits phorbol-12-myristate-13-acetate-induced suppression of cell growth Mus musculus