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Literature summary for 2.4.3.1 extracted from
- beta-Galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation (2007), J. Biol. Chem., 282, 34896-34903.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEP-3B cell | BACE1 affects the alpha2,6-sialylation of proteins secreted from Hep-3B cells. Following BACE1 overexpression in Hep3B cells, the alpha2,6-sialylation of soluble secreted glycoproteins is significantly increased, whereas that of cell-surface glycoproteins remains unchanged | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-galactoside alpha2,6-sialyltransferase I | - |
Homo sapiens |
| ST6Gal I | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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