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Literature summary for 2.4.3.1 extracted from

  • Amano, M.; Galvan, M.; He, J.; Baum, L.G.
    The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death (2003), J. Biol. Chem., 278, 7469-7475.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of the ST6Gal I enzyme in a galectin-1-sensitive murine T cell line Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus addition of alpha2,6-linked sialic acid to the Gal1,4GlcNAc sequence, the preferred ligand for galectin-1, inhibits recognition of this saccharide ligand by galectin-1. The enzyme sialylates N-glycans on CD45, a receptor tyrosine phosphatase that is a T cell receptor for galectin-1. ST6Gal I expression abrogates the reduction in CD45 tyrosine phosphatase activity that results from galectin1 binding. Sialylation of CD45 by the ST6Gal I also prevents galectin-1-induced clustering of CD45 on the T cell surface, an initial step in galectin-1 cell death. Regulation of glycoprotein sialylation may control susceptibility to cell death at specific points during T cell development and peripheral activation ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information addition of alpha2,6-linked sialic acid to the Gal1,4GlcNAc sequence, the preferred ligand for galectin-1, inhibits recognition of this saccharide ligand by galectin-1. The enzyme sialylates N-glycans on CD45, a receptor tyrosine phosphatase that is a T cell receptor for galectin-1. ST6Gal I expression abrogates the reduction in CD45 tyrosine phosphatase activity that results from galectin1 binding. Sialylation of CD45 by the ST6Gal I also prevents galectin-1-induced clustering of CD45 on the T cell surface, an initial step in galectin-1 cell death. Regulation of glycoprotein sialylation may control susceptibility to cell death at specific points during T cell development and peripheral activation Rattus norvegicus ?
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Synonyms

Synonyms Comment Organism
ST6Gal I
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 Rattus norvegicus