Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for antileishmanicidal drug development | Leishmania tarentolae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isodutaduprine | alkaloid from Almeidea rubra, 21.6% inhibition at 0.0356 mM of the recombinant enzyme | Leishmania tarentolae | |
isokokusagine | alkaloid from Almeidea rubra, 44.6% inhibition at 0.0412 mM of the recombinant enzyme | Leishmania tarentolae | |
isoskimmianine | alkaloid from Almeidea rubra, 39.1% inhibition at 0.0386 mM of the recombinant enzyme | Leishmania tarentolae | |
additional information | methanolic and hexanic extracts from roots and leaves of Cedrela fissilis and from fruits, branches and leaves of Cipadessa fruticosa show strong antileishmanicidal activities, the inhibitory activities of plant organ extracts with dichloromethane are lower, overview | Leishmania tarentolae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Leishmania tarentolae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania tarentolae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine | - |
Leishmania tarentolae | AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APRT | - |
Leishmania tarentolae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Leishmania tarentolae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Leishmania tarentolae |