BRENDA - Enzyme Database show
show all sequences of 2.4.2.6

Expanding substrate specificity of nucleoside 2-deoxyribosyltransferase

Kaminski, P.A.; Dugue, L.; Pochet, S.; Nucleic Acids Symp. Ser. 52, 495-496 (2008)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
A15C
is not capable of improving 2',3'-dideoxyribose transfer reaction
Lactobacillus fermentum
A15S
Ser appears a good alternative for Thr, rate of 2',3'-dideoxyribosyl transfer from 2',3'-dideoxycytidine to adenine of the two mutants is almost identical
Lactobacillus fermentum
A15T
a single amino-acid substitution allows the conversion of the nucleoside 2'-deoxyribosyltransferase activity to a nucleoside 2',3'-dideoxy- or 2'3'-didehydro, 2',3'-dideoxyribosyltransferase activity. Specificity for the base is unchanged compared to the wild-type. The mutant displays an improved activity to the transfer of 2',3'-dideoxyribose, which is enhanced by 250fold (depending on the donors and acceptors) while the deoxyribosyl group transfer remains acceptable (30% of the wild-type)
Lactobacillus fermentum
G9S
a single amino-acid substitution allows the conversion of the nucleoside 2'-deoxyribosyltransferase activity to a nucleoside 2',3'-dideoxy- or 2'3'-didehydro, 2',3'-dideoxyribosyltransferase activity
Lactobacillus leichmannii
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Lactobacillus fermentum
Q6YNI5
-
-
Lactobacillus leichmannii
-
-
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.01
-
wild-type, 2',3'-dideoxyadenosine and thymine as substrates; wild-type, 2',3'-dideoxycytidine and thymine as substrates
Lactobacillus fermentum
0.03
-
wild-type, 2',3'-dideoxyadenosine and cytosine as substrates; wild-type, 2,3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
0.036
-
wild-type, 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
0.05
-
wild-type, 2',3'-dideoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
0.06
-
wild-type, 2',3'-dideoxycytidine and adenine as substrates
Lactobacillus fermentum
0.42
-
mutant A15T, 2',3'-dideoxyadenosine and thymine as substrates
Lactobacillus fermentum
0.46
-
mutant A15T, 2'-deoxyadenosine and thymine as substrates
Lactobacillus fermentum
0.5
-
mutant A15T, 2,3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
1.1
-
mutant A15T, 2'-deoxyadenosine and cytosine as substrates
Lactobacillus fermentum
1.29
-
mutant A15T, 2'-deoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
1.35
-
mutant A15T, 2',3'-dideoxyadenosine and cytosine as substrates
Lactobacillus fermentum
1.47
-
mutant A15T, 2',3'-dideoxycytidine and thymine as substrates
Lactobacillus fermentum
1.9
-
mutant A15T, 2'-deoxythymidine and adenine as substrates
Lactobacillus fermentum
6.8
-
mutant A15T, 2',3'-dideoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
6.9
-
wild-type, 2'-deoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
7.1
-
mutant A15T, 2',3'-dideoxycytidine and adenine as substrates
Lactobacillus fermentum
7.11
-
mutant A15T, 2'-deoxycytidine and thymine as substrates
Lactobacillus fermentum
8.4
-
wild-type, 2'-deoxyadenosine and thymine as substrates
Lactobacillus fermentum
9.28
-
mutant A15T, 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
9.3
-
mutant A15T, 2'-deoxycytidine and adenine as substrates
Lactobacillus fermentum
20.1
-
wild-type, 2'-deoxythymidine and adenine as substrates
Lactobacillus fermentum
32
-
wild-type, 2'-deoxycytidine and thymine as substrates
Lactobacillus fermentum
33.2
-
wild-type, 2'-deoxyadenosine and cytosine as substrates
Lactobacillus fermentum
83.7
-
wild-type, 2'-deoxycytidine and adenine as substrates
Lactobacillus fermentum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2',3'-dideoxyadenosine + cytosine
-
705990
Lactobacillus fermentum
2',3'-dideoxycytidine + adenine
-
-
-
?
2',3'-dideoxyadenosine + thymine
-
705990
Lactobacillus fermentum
2',3'-dideoxythymidine + adenine
-
-
-
?
2',3'-dideoxycytidine + adenine
-
705990
Lactobacillus fermentum
2',3'-dideoxyadenosine + cytosine
-
-
-
?
2',3'-dideoxycytidine + hypoxanthine
-
705990
Lactobacillus fermentum
2',3'-dideoxyinosine + cytosine
-
-
-
?
2',3'-dideoxycytidine + thymine
-
705990
Lactobacillus fermentum
2',3'-dideoxythymidine + cytosine
-
-
-
?
2',3'-dideoxythymidine + adenine
-
705990
Lactobacillus fermentum
2',3'-dideoxyadenosine + thymine
-
-
-
?
2',3'didehydro-2',3'-dideoxythymidine + adenine
-
705990
Lactobacillus fermentum
2',3'didehydro-2',3'-dideoxyadenosine + thymine
-
-
-
?
2'-deoxyadenosine + cytosine
-
705990
Lactobacillus fermentum
2'-deoxycytidine + adenine
-
-
-
?
2'-deoxyadenosine + thymine
-
705990
Lactobacillus fermentum
2'-deoxythymidine + adenine
-
-
-
?
2'-deoxycytidine + adenine
-
705990
Lactobacillus fermentum
2'-deoxyadenosine + cytosine
-
-
-
?
2'-deoxycytidine + thymine
-
705990
Lactobacillus fermentum
2'-deoxythymidine + cytosine
-
-
-
?
2'-deoxythymidine + adenine
-
705990
Lactobacillus fermentum
2'-deoxyadenosine + thymine
-
-
-
?
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
A15C
is not capable of improving 2',3'-dideoxyribose transfer reaction
Lactobacillus fermentum
A15S
Ser appears a good alternative for Thr, rate of 2',3'-dideoxyribosyl transfer from 2',3'-dideoxycytidine to adenine of the two mutants is almost identical
Lactobacillus fermentum
A15T
a single amino-acid substitution allows the conversion of the nucleoside 2'-deoxyribosyltransferase activity to a nucleoside 2',3'-dideoxy- or 2'3'-didehydro, 2',3'-dideoxyribosyltransferase activity. Specificity for the base is unchanged compared to the wild-type. The mutant displays an improved activity to the transfer of 2',3'-dideoxyribose, which is enhanced by 250fold (depending on the donors and acceptors) while the deoxyribosyl group transfer remains acceptable (30% of the wild-type)
Lactobacillus fermentum
G9S
a single amino-acid substitution allows the conversion of the nucleoside 2'-deoxyribosyltransferase activity to a nucleoside 2',3'-dideoxy- or 2'3'-didehydro, 2',3'-dideoxyribosyltransferase activity
Lactobacillus leichmannii
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.01
-
wild-type, 2',3'-dideoxyadenosine and thymine as substrates; wild-type, 2',3'-dideoxycytidine and thymine as substrates
Lactobacillus fermentum
0.03
-
wild-type, 2',3'-dideoxyadenosine and cytosine as substrates; wild-type, 2,3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
0.036
-
wild-type, 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
0.05
-
wild-type, 2',3'-dideoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
0.06
-
wild-type, 2',3'-dideoxycytidine and adenine as substrates
Lactobacillus fermentum
0.42
-
mutant A15T, 2',3'-dideoxyadenosine and thymine as substrates
Lactobacillus fermentum
0.46
-
mutant A15T, 2'-deoxyadenosine and thymine as substrates
Lactobacillus fermentum
0.5
-
mutant A15T, 2,3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
1.1
-
mutant A15T, 2'-deoxyadenosine and cytosine as substrates
Lactobacillus fermentum
1.29
-
mutant A15T, 2'-deoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
1.35
-
mutant A15T, 2',3'-dideoxyadenosine and cytosine as substrates
Lactobacillus fermentum
1.47
-
mutant A15T, 2',3'-dideoxycytidine and thymine as substrates
Lactobacillus fermentum
1.9
-
mutant A15T, 2'-deoxythymidine and adenine as substrates
Lactobacillus fermentum
6.8
-
mutant A15T, 2',3'-dideoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
6.9
-
wild-type, 2'-deoxycytidine and hypoxanthine as substrates
Lactobacillus fermentum
7.1
-
mutant A15T, 2',3'-dideoxycytidine and adenine as substrates
Lactobacillus fermentum
7.11
-
mutant A15T, 2'-deoxycytidine and thymine as substrates
Lactobacillus fermentum
8.4
-
wild-type, 2'-deoxyadenosine and thymine as substrates
Lactobacillus fermentum
9.28
-
mutant A15T, 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
Lactobacillus fermentum
9.3
-
mutant A15T, 2'-deoxycytidine and adenine as substrates
Lactobacillus fermentum
20.1
-
wild-type, 2'-deoxythymidine and adenine as substrates
Lactobacillus fermentum
32
-
wild-type, 2'-deoxycytidine and thymine as substrates
Lactobacillus fermentum
33.2
-
wild-type, 2'-deoxyadenosine and cytosine as substrates
Lactobacillus fermentum
83.7
-
wild-type, 2'-deoxycytidine and adenine as substrates
Lactobacillus fermentum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2',3'-dideoxyadenosine + cytosine
-
705990
Lactobacillus fermentum
2',3'-dideoxycytidine + adenine
-
-
-
?
2',3'-dideoxyadenosine + thymine
-
705990
Lactobacillus fermentum
2',3'-dideoxythymidine + adenine
-
-
-
?
2',3'-dideoxycytidine + adenine
-
705990
Lactobacillus fermentum
2',3'-dideoxyadenosine + cytosine
-
-
-
?
2',3'-dideoxycytidine + hypoxanthine
-
705990
Lactobacillus fermentum
2',3'-dideoxyinosine + cytosine
-
-
-
?
2',3'-dideoxycytidine + thymine
-
705990
Lactobacillus fermentum
2',3'-dideoxythymidine + cytosine
-
-
-
?
2',3'-dideoxythymidine + adenine
-
705990
Lactobacillus fermentum
2',3'-dideoxyadenosine + thymine
-
-
-
?
2',3'didehydro-2',3'-dideoxythymidine + adenine
-
705990
Lactobacillus fermentum
2',3'didehydro-2',3'-dideoxyadenosine + thymine
-
-
-
?
2'-deoxyadenosine + cytosine
-
705990
Lactobacillus fermentum
2'-deoxycytidine + adenine
-
-
-
?
2'-deoxyadenosine + thymine
-
705990
Lactobacillus fermentum
2'-deoxythymidine + adenine
-
-
-
?
2'-deoxycytidine + adenine
-
705990
Lactobacillus fermentum
2'-deoxyadenosine + cytosine
-
-
-
?
2'-deoxycytidine + thymine
-
705990
Lactobacillus fermentum
2'-deoxythymidine + cytosine
-
-
-
?
2'-deoxythymidine + adenine
-
705990
Lactobacillus fermentum
2'-deoxyadenosine + thymine
-
-
-
?
Other publictions for EC 2.4.2.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736575
Britos
-
Biotransformation of halogenat ...
Lactobacillus animalis
J. Fluor. Chem.
186
91-96
2016
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1
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1
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1
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736936
Vichier-Guerre
Expedient and generic synthesi ...
Lactobacillus leichmannii
Org. Biomol. Chem.
14
3638-3653
2016
-
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-
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2
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24
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24
-
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-
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-
-
-
-
-
-
736846
Fresco-Taboada
Nucleoside 2'-deoxyribosyltran ...
Bacillus psychrosaccharolyticus, Bacillus psychrosaccharolyticus CECT 4074
Molecules
19
11231-11249
2014
-
-
1
-
-
1
1
-
-
1
2
2
-
6
-
-
1
-
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-
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-
10
1
1
-
1
-
1
-
1
-
-
1
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1
-
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-
1
-
1
-
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-
1
2
2
-
-
-
1
-
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-
-
10
1
1
-
1
-
1
-
1
1
-
-
-
-
-
-
737137
Ye
Ethenoguanines undergo glycosy ...
Lactobacillus fermentum
PLoS ONE
9
e115082
2014
-
-
1
-
-
-
-
-
-
-
-
-
-
6
-
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1
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2
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1
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1
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2
-
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-
722820
Kaminski
Phosphodeoxyribosyltransferase ...
Lactobacillus leichmannii
J. Biol. Chem.
288
6534-6541
2013
-
-
1
-
-
-
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2
-
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2
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6
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2
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1
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2
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6
-
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-
-
2
-
-
-
-
-
-
-
-
2
2
735536
Fresco-Taboada
New insights on nucleoside 2'- ...
Lactobacillus leichmannii, Lactococcus lactis
Appl. Microbiol. Biotechnol.
97
3773-3785
2013
-
-
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2
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2
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6
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2
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6
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-
736587
Fernandez-Lucas
Magnetic chitosan beads for co ...
Lactobacillus reuteri
J. Ind. Microbiol. Biotechnol.
40
955-966
2013
-
-
1
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3
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1
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1
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1
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1
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1
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1
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1
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721851
Fernandez-Lucas
One-step enzymatic synthesis o ...
Lactobacillus reuteri
Biores. Technol.
115
63-69
2012
-
1
-
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6
2
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1
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6
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721371
Fernandez-Lucas
Enzymatic synthesis of nucleos ...
Lactobacillus reuteri
Appl. Microbiol. Biotechnol.
91
317-327
2011
-
1
-
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2
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14
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1
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1
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1
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14
-
1
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1
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-
722294
Lin
Subcellular localization of N- ...
Lactobacillus fermentum, Lactobacillus fermentum CGMCC 1.2133
FEMS Microbiol. Lett.
323
132-141
2011
-
-
1
-
-
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4
-
2
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4
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2
1
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1
-
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-
-
-
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4
-
2
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2
1
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-
721340
Fernandez-Lucas
Lactobacillus reuteri 2-deoxyr ...
Lactobacillus reuteri
Appl. Environ. Microbiol.
76
1462-1470
2010
1
-
1
-
-
-
1
2
-
-
2
-
-
3
-
-
-
-
-
-
-
-
7
1
2
-
2
2
2
-
1
-
-
-
-
1
-
1
-
-
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
7
1
2
-
2
2
2
-
1
-
-
-
-
-
2
2
704429
Kaminski
In vivo reshaping the catalyti ...
Lactobacillus fermentum, Lactobacillus fermentum PAK9, Lactobacillus leichmannii
J. Biol. Chem.
283
20053-20059
2008
-
-
-
-
8
-
-
7
-
-
4
-
-
6
-
-
2
-
-
-
46
-
31
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
7
-
-
4
-
-
-
-
2
-
-
46
-
31
-
-
-
-
7
-
-
-
-
-
-
-
-
7
7
705990
Kaminski
Expanding substrate specificit ...
Lactobacillus fermentum, Lactobacillus leichmannii
Nucleic Acids Symp. Ser.
52
495-496
2008
-
-
-
-
4
-
-
-
-
-
-
-
-
2
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Nucleoside 2-deoxyribosyltrans ...
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7
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Cardinaud
Nucleoside deoxyribosyltransfe ...
Lactobacillus helveticus
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18
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Cardinaud
Nucleoside deoxyribosyltransfe ...
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Deoxyribosyl transfer catalysi ...
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trans-N-Deoxyribosylase: subst ...
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38
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Trans-N-deoxyribosylase from L ...
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