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Information on EC 2.4.2.6 - nucleoside deoxyribosyltransferase
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2.4.2.6 nucleoside deoxyribosyltransferaseIUBMB Comments
Base1 and base2 represent various purines and pyrimidines.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
ndrt, nucleoside 2'-deoxyribosyltransferase, trans-n-deoxyribosylase, ctndt, 2'-deoxyribosyltransferase, drtase i, nucleoside 2-deoxyribosyltransferase, nucleoside deoxyribosyltransferase, landt, drtase ii, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2'-deoxyribosyltransferase
2'-N-deoxyribosyltransferase
Chro_1188
CtNDT
deoxyribose transferase
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deoxyribosyltransferase, nucleoside
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DRTase II
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catalyzes the transfer of the deoxyribosyl moiety between purines or pyrimidines as well as from a purine to a pyrimidine
GQR93_14380
LaNDT
LhNDT
LmPDT
LrNDT
N-deoxyribosyltransferase II
NdRT-II
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NDT
NTD
nucleoside 2'-deoxyribosyltransferase
nucleoside 2'-deoxyribosyltransferase type II
nucleoside 2-deoxyribosyltransferase
nucleoside deoxyribosyltransferase I
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purine nucleoside:purine deoxyribosyltransferase:strictly specific for transfer between purine bases
nucleoside deoxyribosyltransferase II
nucleoside N-deoxyribosyltransferase
nucleoside trans-N-deoxyribosylase
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PDT
purine nucleoside 2'-deoxyribosyltransferase
purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase
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Tb927.5.1360
TbPDT
trans-deoxyribosylase
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trans-N-deoxyribosylase
trans-N-glycosidase
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transdeoxyribosylase
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type I NDT
nucleoside deoxyribosyltransferase II
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purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase:catalyzes the transfer of the deoxyribosyl moiety between purines or pyrimidines as well as from a purine to a pyrimidine
trans-N-deoxyribosylase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
ping-pong bi bi mechanism
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2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
Glu105, Asp-99 and Asn-172 are catalytic active site residues
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2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
Glu90 is a catalytic active site residue, ligand binding and active site structures, overview
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2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
reaction mechanism with oxocarbenium ion as the reaction intermediate, overview
2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pentosyl group transfer
transglycosylation
pentosyl group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase
Base1 and base2 represent various purines and pyrimidines.
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CAS REGISTRY NUMBER
COMMENTARY
9026-86-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2',3'-dideoxyadenosine + 2,6-diaminopurine
2,6-diaminopurine-2',3'-dideoxyriboside + adenine
2',3'-dideoxyadenosine + 6-chloropurine
6-chloropurine-2',3'-dideoxyriboside + adenine
-
-
-
?
2',3'-dideoxyadenosine + 6-mercaptopurine
6-mercaptopurine-2',3'-dideoxyriboside + adenine
low activity
-
-
?
2',3'-dideoxyadenosine + 6-methoxyguanine
6-methoxy-2',3'-dideoxyguanosine + adenine
-
-
-
?
2',3'-dideoxyadenosine + 6-methylpurine
6-methylpurine-2',3'-dideoxyriboside + adenine
low activity
-
-
?
2',3'-dideoxyadenosine + thymine
2',3'-dideoxythymidine + adenine
-
-
-
?
2',3'-dideoxycytidine + thymine
2',3'-dideoxythymidine + cytosine
-
-
-
?
2',3'-dideoxyinosine + 2,6-diaminopurine
2,6-diaminopurine-2',3'dideoxyriboside + inosine
-
-
-
?
2',3'-dideoxyinosine + 6-chloropurine
6-chloropurine-2',3'-dideoxyriboside + inosine
low activity
-
-
?
2',3'-dideoxyinosine + 6-mercaptopurine
6-mercaptopurine-2',3'-dideoxyriboside + inosine
low activity
-
-
?
2',3'-dideoxyinosine + 6-methoxyguanine
6-methoxy-2',3'-dideoxyguanosine + inosine
low activity
-
-
?
2',3'-dideoxyinosine + 6-methylpurine
6-methylpurine-2',3'-dideoxyriboside + inosine
low activity
-
-
?
2',3'didehydro-2',3'-dideoxythymidine + adenine
2',3'didehydro-2',3'-dideoxyadenosine + thymine
2'-deoxyadenosine + 5-fluorouracil
2'-deoxy-D-ribosyl-5-fluorouracil + adenine
reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S
-
-
?
2'-deoxyadenosine + hypoxanthine
2'-deoxyinosine + adenine
-
-
-
?
2'-deoxyadenosine + thymine
2'-deoxythymidine + adenine
-
-
-
?
2'-deoxycytidine + 2,6-diaminopurine
2,6-diaminopurine 2-deoxy-D-riboside + cytosine
reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S
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-
?
2'-deoxycytidine + 5-bromouracil
2'-deoxy-5-bromouridine + cytosine
reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S
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-
?
2'-deoxycytidine + 6-chloroguanine
cytosine + 2'-deoxy-6-chloroguanosine
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DRTase II
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-
?
2'-deoxycytidine + 6-chloropurine
6-chloropurine 2-deoxy-D-ribose 5-phosphate + cytosine
reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S
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-
?
2'-deoxycytidine + adenosine
2'-deoxyadenosine + cytosine
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-
-
-
?
2'-deoxycytidine + thymine
2'-deoxythymidine + cytosine
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-
-
?
2'-deoxyguanosine + 2-fluoroadenine
2-fluoro-2'-deoxyadenosine + guanine
-
-
-
?
2'-deoxyguanosine + 6-chloropurine
6-chloropurine-2'-deoxyriboside + guanine
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-
-
?
2'-deoxyguanosine + 6-mercaptopurine
6-mercaptopurine-2'-deoxyriboside + guanine
-
-
-
?
2'-deoxyguanosine + 6-methoxyguanine
6-methoxy-2'-deoxyguanosine + guanine
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-
-
?
2'-deoxyguanosine + 6-methylpurine
6-methylpurine-2'-deoxyriboside + guanine
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-
-
?
2'-deoxyguanosine + benzimidazole
benzimidazole 2'-deoxyriboside + guanine
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-
-
?
2'-deoxyguanosine + hypoxanthine
2'-deoxyinosine + guanine
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?
2'-deoxyinosine + cytosine
2'-deoxycytidine + hypoxanthine
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?
2'-deoxyinosine + uracil
2'-deoxyuridine + hypoxanthine
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-
-
?
2'-deoxythymidine + 5-azacytosine
5-aza-2'-deoxycytidine + thymine
-
-
-
?
2'-deoxyuridine + 5-ethyluracil
5-ethyl-2'-deoxyuridine + uracil
-
-
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?
2'-deoxyuridine + 5-methylcytosine
5-methyl-2'-deoxycytidine + uracil
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?
2'-deoxyuridine + hypoxanthine
2'-deoxyinosine + uracil
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-
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?
2'-fluoro-2'-deoxyadenosine + guanine
2'-fluoro-2'-deoxyguanosine + adenine
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-
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?
2-fluoro-2'-deoxyinosine + 2,6-diaminopurine
2,6-diaminopurine 2'-deoxyriboside + 2-fluoroinosine
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?
2-fluoro-2'-deoxyinosine + 2-chloroadenine
2-chloro-2'-deoxyadenosine + 2-fluoroinosine
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?
2-fluoro-2'-deoxyinosine + 2-fluoroadenine
2-fluoro-2'-deoxyadenosine + 2-fluoroinosine
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?
2-fluoro-2'-deoxyinosine + 6-chloropurine
6-chloropurine 2'-deoxyriboside + 2-fluoroinosine
low activity
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?
2-fluoro-2'-deoxyinosine + 6-mercaptopurine
6-mercaptopurine 2'-deoxyriboside + 2-fluoroinosine
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-
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?
2-fluoro-2'-deoxyinosine + 6-methoxyguanine
6-methoxyguanine 2'-deoxyriboside + 2-fluoroinosine
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?
2-fluoro-2'-deoxyinosine + 6-methylpurine
6-methylpurine 2'-deoxyriboside + 2-fluoroinosine
low activity
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?
2-fluoro-2'-deoxyinosine + adenine
2'-deoxyadenosine + 2-fluoroinosine
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?
2-fluoro-2'-deoxyinosine + guanine
2'-deoxyguanosine + 2-fluoroinosine
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?
5'-fluoro-5'-thymidine + adenine
5'-fluoro-5'-deoxythymine + adenosine
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deoxyribosyltransferase II
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?
5-iodouracil + 2'-deoxyadenosine
5-iodo-2'-deoxyuridine + adenine
immobilized recombinant enzyme
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-
?
5-iodouracil + 2'-deoxyuridine
5-iodo-2'-deoxyuridine + uracil
immobilized recombinant enzyme
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-
?
9-beta-D-arabinofuranosyl adenine + 2,6-diaminopurine
9-beta-D-arabinofuranosyl 2,6-diaminopurine + adenine
-
-
-
?
9-beta-D-arabinofuranosyl adenine + 2-chloroadenine
9-beta-D-arabinofuranosyl 2-chloroadenine + adenine
-
-
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?
9-beta-D-arabinofuranosyl adenine + 2-fluoroadenine
9-beta-D-arabinofuranosyl 2-fluoroadenine + adenine
-
-
-
?
9-beta-D-arabinofuranosyl adenine + 6-chloropurine
9-beta-D-arabinofuranosyl 6-chloropurine + adenine
-
-
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?
9-beta-D-arabinofuranosyl adenine + 6-methoxyguanine
9-beta-D-arabinofuranosyl 6-methoxyguanine + adenine
-
-
-
?
9-beta-D-arabinofuranosyl adenine + 6-methylpurine
9-beta-D-arabinofuranosyl 6-methylpurine + adenine
-
-
-
?
9-beta-D-arabinofuranosyl adenine + guanine
9-beta-D-arabinofuranosyl guanine + adenine
-
-
-
?
9-beta-D-arabinofuranosyl adenine + hypoxanthine
9-beta-D-arabinofuranosyl hypoxanthine + adenine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + 2,6-diaminopurine
9-beta-D-arabinofuranosyl 2,6-diaminopurine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + 2-chloroadenine
9-beta-D-arabinofuranosyl 2-chloroadenine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + 2-fluoroadenine
9-beta-D-arabinofuranosyl 2-fluoroadenine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + 6-chloropurine
9-beta-D-arabinofuranosyl 6-chloropurine + guanine
low activity
-
-
?
9-beta-D-arabinofuranosyl guanine + 6-mercaptopurine
9-beta-D-arabinofuranosyl 6-mercaptopurine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + 6-methoxyguanine
9-beta-D-arabinofuranosyl 6-methoxyguanine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + 6-methylpurine
9-beta-D-arabinofuranosyl 6-methylpurine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + adenine
9-beta-D-arabinofuranosyl adenine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + hypoxanthine
9-beta-D-arabinofuranosyl hypoxanthine + guanine
-
-
-
?
9-beta-D-arabinofuranosyl guanine + hypoxanthine
?
low activity
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-
?
adenine + deoxycytidine
deoxyadenosine + cytosine
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64.0% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
adenine + deoxyguanosine
deoxyadenosine + guanine
-
46.6% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
adenine + deoxyinosine
deoxyadenosine + hypoxanthine
-
57.3% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
adenine + deoxyuridine
deoxyadenosine + uracil
-
75.4% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
adenine + thymidine
deoxyadenosine + thymine
-
74.6% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
cytosine + deoxyadenosine
deoxycytidine + adenine
-
27.7% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
cytosine + deoxyguanosine
deoxycytidine + guanine
-
25.7% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
cytosine + deoxyinosine
deoxycytidine + hypoxanthine
-
32.0% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
cytosine + deoxyuridine
deoxycytidine + uracil
-
62.9% conversion after 4 h at standard reaction conditions: 2 mM each substrate, 0.013 U NTD, pH 7.5, 25°C, 40 mM (NH4)2SO4, 0.5 mg/ml bovine serum albumin
-
-
r
dAMP + 2,6-dichloropurine
adenine + 2,6-dichloropurin-9-yl-2'-deoxy-beta-D-ribose 5'-phosphate
-
-
-
-
?
dCMP + 2,6-dichloropurine
2,6-dichloropurin-9-yl-2'-deoxy-beta-D-ribose 5'-phosphate + cytosine
reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S
-
-
?
deoxyadenosine + 2-amino 6-methylmercaptopurine
adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-2-amino-6-methylmercaptopurine
-
-
-
-
?
deoxyadenosine + 6-chloroguanine
adenine + 2'-deoxy-6-chloroguanosine
-
-
-
-
?
deoxyadenosine + 6-chloropurine
adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-chloropurine
-
-
-
-
?
deoxyadenosine + 6-dimethylaminopurine
adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-dimethylaminopurine
-
-
-
-
?
deoxyadenosine + 6-methylpurine
adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine
-
-
-
-
?
deoxyadenosine + ethyl 4-amino-1H-imidazole-5-carboxylate
adenine + ethyl 4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-1H-imidazole-5-carboxylate
-
-
-
-
?
deoxyadenosine + hypoxanthine
adenine + deoxyinosine + 7-(beta-D-2'-deoxyribufuranosyl)hypoxanthine
deoxycytidine + 1,7-dimethylguanine
cytosine + deoxy-1,7-dimethylguanosine
-
DRTase II
-
-
?
deoxycytidine + 1,N2-epsilon-guanine
cytosine + ?
-
deoxyribosylation at the N9 atom
-
-
?
deoxycytidine + 1,N6-epsilon-adenine
cytosine + ?
-
deoxyribosylation at the N9 atom
-
-
?
deoxycytidine + 3,N4-epsilon-cytosine
cytosine + ?
-
deoxyribosylation at the N9 atom
-
-
?
deoxycytidine + 5,6,7,9-tetrahydro-7-acetoxy-9-oxoimidazo[1,2-a]purine
cytosine + ?
-
deoxyribosylation at the N9 atom
-
-
?
deoxycytidine + C8-aminoguanine
cytosine + 2'-deoxy-8-aminoguanosine
-
deoxyribosylation at the N9 atom
-
-
?
deoxycytidine + C8-methylguanine
cytosine + 2'-deoxy-8-methylguanosine