BRENDA - Enzyme Database show
show all sequences of 2.4.2.19

Isolation and properties of crystalline quinolinate phosphoribosyltransferase from hog kidney

Shibata, K.; Iwai, K.; Biochim. Biophys. Acta 611, 280-288 (1980)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-oxoglutarate
1 mM, 55% inhibition
Sus scrofa
acetic acid
26% inhibition
Sus scrofa
aspartic acid
1 mM, 37% inhibition
Sus scrofa
Citric acid
1 mM, 89% inhibition
Sus scrofa
formic acid
1 mM, 54% inhibition
Sus scrofa
Fumaric acid
1 mM, 67% inhibition
Sus scrofa
L-Glutamic acid
1 mM, 41% inhibition
Sus scrofa
L-Malic acid
1 mM, 67% inhibition
Sus scrofa
Lactic acid
1 mM, 29% inhibition
Sus scrofa
Maleic acid
1 mM, 42% inhibition
Sus scrofa
oxaloacetic acid
1 mM, 59% inhibition
Sus scrofa
succinic acid
1 mM, 46% inhibition
Sus scrofa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
quinolinate
-
Sus scrofa
0.14
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Sus scrofa
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
absolute requirement for divalent cations. Mg2+ is most effective. Optimal concentrations are 4, 6 and 10 mM for 20, 40 and 100 mM sodium acetate/acetic acid buffer, pH 5.5
Sus scrofa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sus scrofa
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
glycoprotein
enzyme contains 1% mannose
Sus scrofa
Purification (Commentary)
Commentary
Organism
-
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.091
-
-
Sus scrofa
Storage Stability
Storage Stability
Organism
0-4°C, crystalline enzyme is stable for at least 2 years
Sus scrofa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
638028
Sus scrofa
nicotinate D-ribonucleotide + diphosphate + CO2
-
638028
Sus scrofa
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
-
Sus scrofa
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
3
3.5
37°C, denatured abruptly
Sus scrofa
4.5
9.5
37°C, 30 min, completely stable
Sus scrofa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-oxoglutarate
1 mM, 55% inhibition
Sus scrofa
acetic acid
26% inhibition
Sus scrofa
aspartic acid
1 mM, 37% inhibition
Sus scrofa
Citric acid
1 mM, 89% inhibition
Sus scrofa
formic acid
1 mM, 54% inhibition
Sus scrofa
Fumaric acid
1 mM, 67% inhibition
Sus scrofa
L-Glutamic acid
1 mM, 41% inhibition
Sus scrofa
L-Malic acid
1 mM, 67% inhibition
Sus scrofa
Lactic acid
1 mM, 29% inhibition
Sus scrofa
Maleic acid
1 mM, 42% inhibition
Sus scrofa
oxaloacetic acid
1 mM, 59% inhibition
Sus scrofa
succinic acid
1 mM, 46% inhibition
Sus scrofa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
quinolinate
-
Sus scrofa
0.14
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Sus scrofa
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
absolute requirement for divalent cations. Mg2+ is most effective. Optimal concentrations are 4, 6 and 10 mM for 20, 40 and 100 mM sodium acetate/acetic acid buffer, pH 5.5
Sus scrofa
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
glycoprotein
enzyme contains 1% mannose
Sus scrofa
Purification (Commentary) (protein specific)
Commentary
Organism
-
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.091
-
-
Sus scrofa
Storage Stability (protein specific)
Storage Stability
Organism
0-4°C, crystalline enzyme is stable for at least 2 years
Sus scrofa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
638028
Sus scrofa
nicotinate D-ribonucleotide + diphosphate + CO2
-
638028
Sus scrofa
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
-
Sus scrofa
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
3
3.5
37°C, denatured abruptly
Sus scrofa
4.5
9.5
37°C, 30 min, completely stable
Sus scrofa
Other publictions for EC 2.4.2.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737258
Youn
Structural insights into the q ...
Homo sapiens
Sci. Rep.
6
19681
2016
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1
1
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1
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1
1
-
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-
737126
Kim
Biochemical characterization o ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS ONE
9
e100062
2014
-
-
1
-
5
-
2
2
-
5
1
2
-
3
-
-
1
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-
-
2
-
2
-
1
-
-
2
1
1
-
-
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-
4
-
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1
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-
5
-
4
2
-
2
-
5
1
2
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1
-
-
2
-
2
-
1
-
-
2
1
1
-
-
-
-
-
-
-
-
737213
Malik
The crystal structure of human ...
Homo sapiens
Proteins
82
405-414
2014
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1
1
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1
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1
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1
1
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727776
Sorci
uinolinate salvage and insight ...
Streptococcus pyogenes, Streptococcus pyogenes ATCC BAA-946
J. Bacteriol.
195
726-732
2013
-
-
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1
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1
2
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2
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2
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1
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737108
Youn
Crystal structure of Sus scrof ...
Sus scrofa
PLoS ONE
8
e62027
2013
-
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-
1
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-
-
-
-
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1
1
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7
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1
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1
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1
1
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1
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1
1
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1
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1
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1
1
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721223
Youn
Crystallization and preliminar ...
Sus scrofa
Acta Crystallogr. Sect. F
68
1488-1490
2012
-
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-
1
-
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2
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1
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2
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1
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1
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2
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1
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723484
Ryan
Structure and expression of th ...
Nicotiana tabacum
Plant Sci.
188-189
102-110
2012
-
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1
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-
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-
-
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7
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1
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1
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721207
Kang
Crystallization and preliminar ...
Homo sapiens
Acta Crystallogr. Sect. F
67
38-40
2011
-
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1
1
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2
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1
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1
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1
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1
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1
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-
702358
Bello
Interactions at the 2 and 5 po ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
49
1377-1387
2010
-
-
1
-
6
-
-
12
-
-
-
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-
2
-
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1
-
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1
1
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6
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1
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6
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12
-
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1
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1
1
-
-
-
6
-
-
-
-
-
-
-
-
11
11
702359
Bello
Roles for cationic residues at ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
49
1388-1395
2010
-
-
1
-
5
-
-
11
-
-
-
-
-
3
-
-
1
-
-
-
4
-
2
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-
5
-
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1
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5
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11
-
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1
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4
-
2
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5
-
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-
-
-
1
1
-
11
11
721705
Ishidoh
Quinolinate phosphoribosyl tra ...
Homo sapiens
Biochim. Biophys. Acta
1803
527-533
2010
-
-
1
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1
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702234
di Luccio
Comprehensive X-ray structural ...
Saccharomyces cerevisiae
Biochemistry
47
4039-4050
2008
-
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1
1
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1
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1
1
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2
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1
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1
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1
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693620
Liu
Structural and kinetic charact ...
Homo sapiens
J. Mol. Biol.
373
755-763
2007
-
-
1
1
9
-
1
3
-
1
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1
-
3
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1
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-
2
-
3
1
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2
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1
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1
9
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1
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3
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1
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1
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1
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2
-
3
1
-
-
-
2
-
-
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-
677680
Wang
Involvement of quinolinate pho ...
Burkholderia sp., Burkholderia sp. PsJN
Appl. Environ. Microbiol.
72
760-768
2006
-
-
1
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-
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2
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9
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1
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682749
Kim
Crystal structure of quinolini ...
Helicobacter pylori
Proteins
63
252-255
2006
-
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1
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1
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2
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1
1
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659608
Zheng
Changes in trigonelline (N-met ...
Vigna radiata var. radiata
J. Exp. Bot.
56
1615-1623
2005
-
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1
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1
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1
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5
1
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2
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1
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1
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-
-
-
-
-
-
-
663365
Schwarzenbacher
Crystal structure of a type II ...
Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
Proteins Struct. Funct. Bioinform.
55
768-771
2004
-
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1
1
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1
2
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3
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1
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1
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4
1
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1
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638032
Kim
Crystallization and preliminar ...
Helicobacter pylori
Acta Crystallogr. Sect. D
59
1265-1266
2003
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1
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1
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4
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638031
Panozzo
Aerobic and anaerobic NAD+ met ...
Saccharomyces cerevisiae
FEBS Lett.
517
97-102
2002
-
-
-
-
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-
-
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1
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2
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638035
Cao
Quinolinate phosphoribosyltran ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
41
3520-3528
2002
-
-
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3
2
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2
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1
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1
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1
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3
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3
3
2
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1
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1
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638034
Sinclair
Molecular characterization of ...
Nicotiana rustica, Nicotiana sylvestris, Nicotiana tabacum
Plant Mol. Biol.
44
603-617
2000
-
-
2
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3
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8
-
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3
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6
-
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2
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3
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3
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6
-
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-
-
-
-
638033
Chang
Role of quinolinate phosphorib ...
Burkholderia cepacia
J. Bacteriol.
181
3069-3075
1999
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-
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2
-
-
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-
-
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-
-
-
-
638037
Fukuoka
Characterization and functiona ...
Homo sapiens
Biochim. Biophys. Acta
1395
192-201
1998
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-
1
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-
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1
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4
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2
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2
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1
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638038
Sharma
Crystal structure of quinolini ...
Mycobacterium tuberculosis
Structure
6
1587-1599
1998
-
-
1
1
-
-
-
-
-
-
-
1
-
4
-
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2
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1
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1
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1
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-
2
-
-
-
-
-
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-
-
-
-
-
-
-
-
638039
Eads
A new function for a common fo ...
Salmonella enterica subsp. enterica serovar Typhimurium
Structure
5
47-58
1997
-
-
-
1
-
-
-
-
-
-
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3
-
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
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-
638020
Bhatia
The sequencing, expression, pu ...
Escherichia coli
Arch. Biochem. Biophys.
325
270-278
1996
-
-
1
-
-
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4
2
-
1
2
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-
3
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1
1
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1
1
1
1
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-
-
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1
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4
-
2
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1
2
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1
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1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638022
Hughes
The Salmonella typhimurium nad ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Bacteriol.
175
479-486
1993
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1
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4
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1
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1
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1
1
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1
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4
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2
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1
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-
1
-
1
1
-
-
-
-
-
-
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-
-
-
-
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-
638027
Okuno
Quinolinic acid phosphoribosyl ...
Homo sapiens
J. Biochem.
103
1054-1059
1988
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1
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1
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4
2
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1
1
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1
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-
-
-
-
-
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1
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3
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1
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4
2
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
638026
Okuno
Purification of quinolinic aci ...
Rattus norvegicus
Biochim. Biophys. Acta
841
112-119
1985
-
-
-
-
-
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1
3
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2
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2
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1
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-
4
1
-
1
1
-
-
1
-
1
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-
1
-
-
-
-
-
-
-
-
-
-
1
1
3
-
-
2
-
-
-
-
1
-
4
1
-
1
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
638014
Wagner
-
Determination of quinolinic ac ...
Nicotiana tabacum
Phytochemistry
23
1881-1883
1984
-
-
-
-
-
-
-
2
-
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-
1
-
1
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4
-
1
2
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2
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1
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4
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638015
Iwai
Crystallization and properties ...
Sus scrofa
Methods Enzymol.
66
96-101
1980
-
-
-
1
-
-
7
2
-
1
3
-
-
1
-
-
1
1
-
1
1
-
1
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
1
-
-
-
7
1
2
-
1
3
-
-
-
-
1
-
1
1
-
1
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
638017
Shibata
-
Effect of 5-phosphoribosyl-1-p ...
Sus scrofa
Agric. Biol. Chem.
44
2785-2791
1980
-
-
-
1
-
-
1
-
-
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1
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-
-
2
1
-
1
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-
3
-
-
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2
-
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-
-
-
1
-
-
-
1
2
-
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-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
638028
Shibata
Isolation and properties of cr ...
Sus scrofa
Biochim. Biophys. Acta
611
280-288
1980
-
-
-
-
-
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12
2
-
1
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-
-
1
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1
1
-
-
1
1
1
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
12
-
2
-
1
-
-
-
-
1
1
-
1
1
1
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
638030
Shibata
-
Crystalline quinolinate phosph ...
Cupriavidus necator
Agric. Biol. Chem.
44
119-123
1980
1
-
-
-
-
-
19
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
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-
-
1
-
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-
-
2
-
-
1
-
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-
-
-
-
-
19
2
4
-
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-
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-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
638021
Iwai
-
Crystalline quinolinate phosph ...
Sus scrofa
Agric. Biol. Chem.
43
351-355
1979
-
-
-
-
-
-
10
-
-
-
-
-
-
1
-
-
-
-
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1
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-
1
-
-
-
-
-
-
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-
-
-
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-
-
-
-
-
-
-
-
-
10
-
-
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-
-
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-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638029
Iwai
-
Properties of crystalline quin ...
Cupriavidus necator
Agric. Biol. Chem.
43
345-350
1979
-
-
-
-
-
-
1
2
-
2
2
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1
-
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-
1
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
2
2
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
638019
Musick
Preliminary crystallographic s ...
Sus scrofa
J. Mol. Biol.
117
1101-1107
1977
-
-
-
1
-
-
-
-
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2
4
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1
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-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
4
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638018
Taguchi
-
Inhibition of hog liver crysta ...
Sus scrofa
Agric. Biol. Chem.
40
385-389
1976
-
-
-
-
-
-
20
-
-
1
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
20
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638024
Taguchi
-
The isolation and physicochemi ...
Sus scrofa
Agric. Biol. Chem.
39
1493-1500
1975
-
-
-
-
-
-
-
-
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3
1
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1
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-
1
-
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
1
-
-
-
1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638025
Taguchi
-
Properties of the crystalline ...
Sus scrofa
Agric. Biol. Chem.
39
1599-1604
1975
-
-
-
-
-
-
16
2
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4
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1
-
1
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-
-
-
-
1
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
2
-
4
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
638012
Taguchi
Purification and properties of ...
Lentinula edodes
J. Nutr. Sci. Vitaminol.
20
269-281
1974
-
-
-
-
-
-
-
2
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1
1
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-
1
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-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
638013
Taguchi
Characteristics of quinolinate ...
Lentinula edodes
J. Nutr. Sci. Vitaminol.
20
283-291
1974
-
-
-
-
-
-
7
-
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-
1
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-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
638016
Mann
Quinolinic acid phosphoribosyl ...
Ricinus communis
J. Biol. Chem.
249
6817-6823
1974
-
-
-
-
-
-
5
2
-
-
3
-
-
2
-
-
-
-
-
3
1
1
1
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
2
-
-
3
-
-
-
-
-
-
3
1
1
1
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
638023
Iwai
Purification and crystallizati ...
Sus scrofa
Biochem. Biophys. Res. Commun.
56
884-891
1974
-
-
1
1
-
-
-
-
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3
1
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1
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1
-
-
-
1
-
2
2
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-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
1
-
-
1
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638010
Packman
-
Crystalline quinolinate phosph ...
Pseudomonas sp.
J. Biol. Chem.
240
PC4107-PC4108
1965
-
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-
1
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-
-
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1
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1
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1
-
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-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
638011
Gholson
The enzymatic conversion of qu ...
Bos taurus
J. Biol. Chem.
239
1208-1214
1964
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1
3
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5
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1
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1
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-
1
1
-
2
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-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
3
-
5
-
-
-
-
-
1
-
1
1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-