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Information on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)
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2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating)IUBMB Comments
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes .
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Word Map
- 2.4.2.19
-
nicotinic
-
3-hydroxyanthranilic
-
phthalic
- tiazofurin
-
excitotoxin
- kynureninase
-
5-phosphoribosyl-1-pyrophosphate
-
4.1.1.45
-
phosphoribosyltransferases
-
prtases
- aminocarboxymuconate-semialdehyde
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
quinolinate phosphoribosyltransferase, quinolinic acid phosphoribosyltransferase, qaprtase, qprtase, nad pyrophosphorylase, quinolinate phosphoribosyl transferase, hqprtase, spnadc, quinolate phosphoribosyltransferase, quinolinate phosphoribosyltransferase 2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
general stress protein 70
-
-
-
-
GSP70
-
-
-
-
M6_Spy1061
NAD pyrophosphorylase
-
-
-
-
NadC
nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19)
-
-
-
-
nicotinate-nucleotide pyrophosphorylase (carboxylating)
-
-
-
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nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating)
-
-
-
-
pyrophosphorylase, nicotinate mononucleotide (carboxylating)
-
-
-
-
QAPRTase
QPRTase
QPRTase
-
-
-
-
QPT
quinolinate phosphoribosyl transferase
quinolinate phosphoribosyltansferase
quinolinate phosphoribosyltransferase
quinolinate phosphoribosyltransferase (decarboxylating)
-
-
-
-
quinolinate phosphoribosyltransferase [decarboxylating]
-
-
-
-
quinolinic acid phosphoribosyl transferase
quinolinic acid phosphoribosyltransferase
quinolinic phosphoribosyltransferase
-
-
-
-
sp.NadC
spNadC
TM1645
type II quinolic acid phosphoribosyltransferase
NadC
-
-
-
-
QAPRTase
-
-
-
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quinolinate phosphoribosyltransferase
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-
-
-
quinolinate phosphoribosyltransferase
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quinolinic acid phosphoribosyltransferase
-
-
-
-
type II quinolic acid phosphoribosyltransferase
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
formation of a ternary complex consisting the enzyme, pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate
-
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
formation of a ternary complex comprising the enzyme, quinolinate and 5-phosphoribosyl-1-diphosphate
-
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
predominantly ordered kinetic mechanism in which productive binding of quinolinate precedes that of 5-phospho-alpha-D-ribose 1-diphosphate
-
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
ordered binding mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pentosyl group transfer
pentosyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3].
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CAS REGISTRY NUMBER
COMMENTARY
37277-74-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
beta-nicotinate D-ribonucleotide + diphosphate + CO2
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
M1KCW7
-
-
-
?
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
beta-nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate + H+
beta-nicotinate D-ribonucleotide + diphosphate + CO2
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
-
-
-
?
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
-
-
-
?
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
r
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
essential enzyme in the NAD+ biosynthetic pathway
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
ir
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
type II phosphoribosyltransfer followed by irreversible decarboxylation, involved in catabolism of quinolinic acid and in NAD+ de novo synthesis
-
-
ir
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
i.e. beta-niacin mononucleotide
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
enzyme provides the de novo source of nicotinate mononucleotide
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
enzyme provides the de novo source of nicotinate mononucleotide
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
synthesis of precursors for trigonelline biosynthesis, feeding experiments, overview
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
direct conversion of quinolinic acid to nicotinic acid mononucleotide
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate + H+
beta-nicotinate D-ribonucleotide + diphosphate + CO2
-
Burkholderia sp. strain PsJN stimulates root growth of potato explants compared to uninoculated controls under gnotobiotic conditions. QAPRTase may play a role in the signal pathway for promotion of plant growth by PsJN
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate + H+
beta-nicotinate D-ribonucleotide + diphosphate + CO2
-
Burkholderia sp. strain PsJN stimulates root growth of potato explants compared to uninoculated controls under gnotobiotic conditions. QAPRTase may play a role in the signal pathway for promotion of plant growth by PsJN
-
-
?
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
-
-
-
?
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
-
-
-
-
?
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
6 mM MgCl2, pH7.2, 37°C, 0.3 mM quinolinic acid, HPLC-based assay: 7 microgram purified enzyme, 1 mM 5-phospho-alpha-D-ribose 1-diphosphate, 20 min, UV-based assay: 14 microgram purified enzyme, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, 30 min
HPLC-based assay: 254 nm (quantification of nicotinic acid mononucleotide and quinolinic acid), UV-based assay: 266 nm (quantification of nicotinic acid mononucleotide)
-
ir
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
-
-
-
?
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
-
-
-
?
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
-
-
-
?
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
-
Arg175 is essential for catalysis, critical role for Lys185 in the chemistry of the QAPRTase intermediate, interfacial role for Arg118 during catalysis
-
-
?
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
-
Lys153 is necessary for catalysis and important for 5-phospho-alpha-D-ribose 1-diphosphate binding, Glu214 provides a hydrogen bond necessary for catalysis but does not act as a base or electrostatically to stabilize the transition state, Lys284 is involved in 5-phospho-alpha-D-ribose 1-diphosphate binding, and Asp235 is not essential
-
-
?
additional information
?
-
-
the recruitment of this gene for growth on phthalate gives Burkholderia cepacia an advantage over other phthalate-degrading bacteria in the environment
-
-
?
additional information
?
-
-
key enzyme in catabolism of quinolinate. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders
-
-
?
additional information
?
-
no detectable activity for mutants R161Q, R138Q, K171A, K171S, K139A, K139S, 6 mM MgCl2, pH7.2, 37°C, 0.3 mM quinolinic acid, UV-based assay: 14 microgram purified enzyme, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, 30 min
-
-
?
additional information
?
-
-
no detectable activity for mutants R161Q, R138Q, K171A, K171S, K139A, K139S, 6 mM MgCl2, pH7.2, 37°C, 0.3 mM quinolinic acid, UV-based assay: 14 microgram purified enzyme, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, 30 min
-
-
?
additional information
?
-
-
essential enzyme for the de novo biosynthesis of NAD+
-
-
?
additional information
?
-
-
key enzyme in NAD+ biosynthesis, also plays an important role in ensuring nicotinic acid available for the synthesis of defensive pyridine alkaloids
-
-
?
additional information
?
-
-
key enzyme in NAD+ biosynthesis, also plays an important role in ensuring nicotinic acid available for the synthesis of defensive pyridine alkaloids
-
-
?
additional information
?
-
-
key enzyme in NAD+ biosynthesis, also plays an important role in ensuring nicotinic acid available for the synthesis of defensive pyridine alkaloids
-
-
?
additional information
?
-
-
enzyme is probably involved in the regulation of nicotine biosynthesis
-
-
?
additional information
?
-
-
intermediary enzyme in the de novo NAD biosynthetic pathway
-
-
?
additional information
?
-
-
intermediary enzyme in the de novo NAD biosynthetic pathway
-
-
?
additional information
?
-
-
intermediary enzyme in the de novo NAD biosynthetic pathway
-
-
?
additional information
?
-
-
intermediary enzyme in the de novo NAD biosynthetic pathway
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
beta-nicotinate D-ribonucleotide + diphosphate + CO2
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
M1KCW7
-
-
-
?
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
beta-nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate + H+
beta-nicotinate D-ribonucleotide + diphosphate + CO2
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
r
phosphoribosyl diphosphate + quinolinic acid
nicotinate mononucleotide + diphosphate + CO2
-
-
-
r
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
essential enzyme in the NAD+ biosynthetic pathway
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
type II phosphoribosyltransfer followed by irreversible decarboxylation, involved in catabolism of quinolinic acid and in NAD+ de novo synthesis
-
-
ir
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
enzyme provides the de novo source of nicotinate mononucleotide
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
enzyme provides the de novo source of nicotinate mononucleotide
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinate D-ribonucleotide + diphosphate + CO2
-
synthesis of precursors for trigonelline biosynthesis, feeding experiments, overview
-
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate + H+
beta-nicotinate D-ribonucleotide + diphosphate + CO2
-
Burkholderia sp. strain PsJN stimulates root growth of potato explants compared to uninoculated controls under gnotobiotic conditions. QAPRTase may play a role in the signal pathway for promotion of plant growth by PsJN
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pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate + H+
beta-nicotinate D-ribonucleotide + diphosphate + CO2
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Burkholderia sp. strain PsJN stimulates root growth of potato explants compared to uninoculated controls under gnotobiotic conditions. QAPRTase may play a role in the signal pathway for promotion of plant growth by PsJN
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quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
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quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
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quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
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quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinic acid mononucleotide + diphosphate + CO2
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additional information
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the recruitment of this gene for growth on phthalate gives Burkholderia cepacia an advantage over other phthalate-degrading bacteria in the environment
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key enzyme in catabolism of quinolinate. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders
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essential enzyme for the de novo biosynthesis of NAD+
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additional information
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key enzyme in NAD+ biosynthesis, also plays an important role in ensuring nicotinic acid available for the synthesis of defensive pyridine alkaloids
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additional information
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key enzyme in NAD+ biosynthesis, also plays an important role in ensuring nicotinic acid available for the synthesis of defensive pyridine alkaloids
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additional information
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key enzyme in NAD+ biosynthesis, also plays an important role in ensuring nicotinic acid available for the synthesis of defensive pyridine alkaloids
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additional information
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enzyme is probably involved in the regulation of nicotine biosynthesis
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intermediary enzyme in the de novo NAD biosynthetic pathway
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additional information
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intermediary enzyme in the de novo NAD biosynthetic pathway
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additional information
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intermediary enzyme in the de novo NAD biosynthetic pathway
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additional information
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intermediary enzyme in the de novo NAD biosynthetic pathway
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Mn2+
additional information
not stimulated by Ca2+, Zn2+, and Cu2+
Mg2+
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absolute requirement for a divalent metal ion, Mg2+ is most effective, optimal activity at 1.5 mM
Mg2+
the enzyme requires bivalent metal ions and its activity is highest in the presence of Mg2+
Mg2+
required for activity, 6 mM used in assay conditions
Mg2+
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absolute requirement for divalent cations. Mg2+ is most effective. Optimal concentrations are 4, 6 and 10 mM for 20, 40 and 100 mM sodium acetate/acetic acid buffer, pH 5.5
Mg2+
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absolute requirement. Optimal concentration is 1 mM in absence of ATP and 7 mM in presence of ATP at 5 mM
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
5-phospho-alpha-D-ribose 1-diphosphate
substrate inhibition, mixed inhibition (competitive and non-competitive) above 0.3 mM 5-phospho-alpha-D-ribose 1-diphosphate
D-fructose-1,6-diphosphate
competitive with respect to 5-phosphoribosyl-1-diphosphate and noncompetitive with respect to quinolinate
diphosphate
noncompetitive with respect to both 5-phosphoribosyl-1-diphosphate and quinolinate