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Information on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)

for references in articles please use BRENDA:EC2.4.2.19

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IUBMB Comments

The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
quinolinate phosphoribosyltransferase, quinolinic acid phosphoribosyltransferase, qaprtase, qprtase, nad pyrophosphorylase, quinolinate phosphoribosyl transferase, hqprtase, spnadc, quinolate phosphoribosyltransferase, quinolinate phosphoribosyltransferase 2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, NAD de novo biosynthesis I, NAD de novo biosynthesis III, NAD de novo biosynthesis IV (anaerobic), nicotine biosynthesis, superpathway of nicotine biosynthesis