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Information on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)

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IUBMB Comments
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
quinolinate phosphoribosyltransferase, quinolinic acid phosphoribosyltransferase, qaprtase, qprtase, nad pyrophosphorylase, quinolinate phosphoribosyl transferase, hqprtase, quinolate phosphoribosyltransferase, quinolinate phosphoribosyltransferase 2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
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