Literature summary for 2.4.2.18 extracted from

Kubota, T.; Matsushita, H.; Tomita, T.; Kosono, S.; Yoshida, M.; Kuzuyama, T.; Nishiyama, M.
Novel stand-alone RAM domain protein-mediated catalytic control of anthranilate phosphoribosyltransferase in tryptophan biosynthesis in Thermus thermophilus (2017), Extremophiles, 21, 73-83 .

Search for more literature for 2.4.2.18

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL cells	Thermus thermophilus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	enzyme activity is not affected by the sole addition of SraA, Trp, Ile, Leu or Ser	Thermus thermophilus
tryptophan	the enzyme is inhibited by tryptophan only in the presence of increasing amounts of stand-alone RAM domain protein SraA. Tryptophan acts as a specific inhibitor of the enzyme by binding to SraA	Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate	Thermus thermophilus	-	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Thermus thermophilus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Strep-Tactin column chromatography	Thermus thermophilus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate	-	Thermus thermophilus	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 36000, His-tagged enzyme, SDS-PAGE	Thermus thermophilus

Synonyms

Synonyms	Comment	Organism
AnPRT	-	Thermus thermophilus
TTC1491	-	Thermus thermophilus

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Release 2023.1 (January 2023)