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Information on EC 2.4.2.18 - anthranilate phosphoribosyltransferase
for references in articles please use BRENDA:EC2.4.2.18
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.2 Pentosyltransferases
2.4.2.18 anthranilate phosphoribosyltransferase
IUBMB Comments
In some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan [EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].
The enzyme appears in viruses and cellular organisms
- 2.4.2.18
-
phosphoribosyltransferases
- chorismate
-
sulfolobus
- solfataricus
- phosphorylases
-
indole-3-glycerol
-
glutamine-dependent
- hafniae
-
4.1.3.27
Reaction Schemes
showSynonyms
anthranilate phosphoribosyltransferase, anprt, anthranilate phosphoribosyl transferase, phosphoribosylanthranilate transferase, ssanprt, sanprt, sstrpd, anthranilate prt, trp d, anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AnPRT
anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase
-
-
-
-
anthranilate phosphoribosyl transferase
anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase
-
-
-
-
anthranilate phosphoribosyltransferase
anthranilate-5-phosphoribosylphosphate phosphoribosyltransferase
-
-
-
-
anthranilate-PP-ribose-P phosphoribosyltransferase
-
-
-
-
phosphoribosyl-anthranilate pyrophosphorylase
-
-
-
-
phosphoribosylanthranilate pyrophosphorylase
-
-
-
-
phosphoribosylanthranilate transferase
phosphoribosyltransferase, anthranilate
-
-
-
-
PR transferase
-
-
-
-
PRT
-
-
-
-
sAnPRT
SSO0890
strpD
TrpD
additional information
anthranilate phosphoribosyl transferase
-
bifunctional enzyme EC 4.1.3.27, 2.4.2.18
phosphoribosylanthranilate transferase
-
-
-
-
TrpD
-
-
-
-
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
-
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
Enterobacter liquefaciens
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
-
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
enzyme is component II of the anthranilate synthase-phosphoribosyl transferase complex
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
additional information
-
in some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20, EC 5.3.1.24)
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
reaction mechanism
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pentosyl group transfer
pentosyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
L-tryptophan biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase
In some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan [EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].
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CAS REGISTRY NUMBER
COMMENTARY
9059-35-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-amino-2-pentenoate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-2-amino-2-pentenoate + diphosphate
Substrates: good substrate
Products: -
Products: -
?
2-aminoacrylate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-2-aminoacrylate + diphosphate
Substrates: -
Products: -
Products: -
?
2-aminocrotonate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-2-aminocrotonate + diphosphate
ammonia + 5-phospho-alpha-D-ribose 1-diphosphate
phosphoribosyl amine + diphosphate
-
Substrates: anthranilate synthase-phosphoribosyl transferase complex subunit TrpD in vitro
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
2-aminocrotonate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-2-aminocrotonate + diphosphate
Substrates: good substrate
Products: -
Products: -
?
2-aminocrotonate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-2-aminocrotonate + diphosphate
-
Substrates: -
Products: reaction product predicted to be a phosphoribosyl-enamine adduct, which breaks down directly into phosphoribosyl amine and 2-ketobutyrate (a reaction mediated by TrpD or non-enzymatic), or which breaks down non-enzymatically into ribose 5'-phosphate, 2-ketobutyrate and NH3. Ribose 5'-phosphate and NH3 combine non-enzymatically to form phosphoribosyl amine
Products: reaction product predicted to be a phosphoribosyl-enamine adduct, which breaks down directly into phosphoribosyl amine and 2-ketobutyrate (a reaction mediated by TrpD or non-enzymatic), or which breaks down non-enzymatically into ribose 5'-phosphate, 2-ketobutyrate and NH3. Ribose 5'-phosphate and NH3 combine non-enzymatically to form phosphoribosyl amine
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: the enzyme is required for tryptophan biosynthesis, and is involved, in coordination with several other enzymes, in defense responses of the plant, e.g. in case of pathogen infection or after treatment with acifluorfen
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Enterobacter liquefaciens
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Enterobacter liquefaciens
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
r
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Pelodictyon luteolum DSM270
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: tryptophan biosynthesis, class III phosphoribosyltransfer
Products: -
Products: -
ir
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: 37Ā°C, pH 7.2, 0.05 mM Mg2+
Products: -
Products: -
ir
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: catalyzes the third step in tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: catalyzes the third step in tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: generation of phosphoribosyl amine from 5-phospho-alpha-D-ribose 1-diphosphate is a step in thiamine biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: reaction is catalyzed by the TrpD subunit of the anthranilate synthase-phosphoribosyl transferase complex
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase, composed of the TrpD and TrpE proteins, is essential for phosphoribosyl amine formation in strains lacking both yjgF and purF
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: also 4- and 5-carbon enamines (2-aminocrotonate, 2-amino-2-pentenoate, also 2-aminoacrylate) serve as substrates, 2-aminobutyrate is not used as substrate
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Substrates: -
Products: -
Products: -
r
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with 2-aminobutyrate
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with 2-aminobutyrate
Products: -
Products: -
?
additional information
?
-
-
Substrates: connections between purine, thiamine, and tryptophan biosynthetic pathways, overview, the enzyme complex can substitute for PurF in formation of phosphoribosyl amine in vivo
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
additional information
?
-
-
Substrates: connections between purine, thiamine, and tryptophan biosynthetic pathways, overview, the enzyme complex can substitute for PurF in formation of phosphoribosyl amine in vivo
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: the enzyme is required for tryptophan biosynthesis, and is involved, in coordination with several other enzymes, in defense responses of the plant, e.g. in case of pathogen infection or after treatment with acifluorfen
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Enterobacter liquefaciens
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
r
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Pelodictyon luteolum DSM270
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: tryptophan biosynthesis, class III phosphoribosyltransfer
Products: -
Products: -
ir
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: catalyzes the third step in tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: catalyzes the third step in tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: generation of phosphoribosyl amine from 5-phospho-alpha-D-ribose 1-diphosphate is a step in thiamine biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase, composed of the TrpD and TrpE proteins, is essential for phosphoribosyl amine formation in strains lacking both yjgF and purF
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: enzyme of tryptophan biosynthesis
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
Substrates: -
Products: -
Products: -
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Substrates: -
Products: -
Products: -
r
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Substrates: -
Products: -
Products: -
?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Substrates: -
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Zn2+
the enzyme shows highest activity with 0.1 mM Zn2+. The enzyme contains a total of 6 Zn2+ ions in the dimer
additional information
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-(2-carboxyphenylamino)-5-(3-phosphonopropoxy)benzoic acid
-
2-(2-carboxyphenylamino)-5-(4-phosphonobutoxy)benzoic acid
-
2-(2-carboxyphenylamino)-5-(5-phosphonopentyloxy)benzoic acid
-
N-(5-phospho-D-ribosyl)-anthranilate
-
-
tryptophan
-
the enzyme is inhibited by tryptophan only in the presence of increasing amounts of stand-alone RAM domain protein SraA. Tryptophan acts as a specific inhibitor of the enzyme by binding to SraA
Zn2+
concentrations higher than 0.1 mM Zn2+ inhibit the enzyme activity (about 80% residual activity at 0.3 mM, about 65% residual activity at 0.5 mM, about 20% residual activity at 1.0 mM)
additional information
-
enzyme activity is not affected by the sole addition of SraA, Trp, Ile, Leu or Ser
-