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Literature summary for 2.4.1.347 extracted from

  • Asencion Diez, M.; Demonte, A.; Syson, K.; Arias, D.; Gorelik, A.; Guerrero, S.; Bornemann, S.; Iglesias, A.
    Allosteric regulation of the partitioning of glucose-1-phosphate between glycogen and trehalose biosynthesis in Mycobacterium tuberculosis (2015), Biochim. Biophys. Acta, 1850, 13-21 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.347

Activating Compound

Activating Compound Comment Organism Structure
fructose-6-phosphate the activity of the enzyme is increased up to 2fold by fructose-6-phosphate Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-alpha-D-glucose + D-glucose 6-phosphate Mycobacterium tuberculosis
-
 ADP + alpha,alpha-trehalose 6-phosphate
-
 ?
ADP-alpha-D-glucose + D-glucose 6-phosphate Mycobacterium tuberculosis H37Rv
-
 ADP + alpha,alpha-trehalose 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP-alpha-D-glucose + D-glucose 6-phosphate
-
 Mycobacterium tuberculosis ADP + alpha,alpha-trehalose 6-phosphate
-
 ?
ADP-alpha-D-glucose + D-glucose 6-phosphate
-
 Mycobacterium tuberculosis H37Rv ADP + alpha,alpha-trehalose 6-phosphate
-
 ?
UDP-alpha-D-glucose + D-glucose 6-phosphate the enzyme exhibits less activity with UDP-alpha-D-glucose compared to ADP-alpha-D-glucose Mycobacterium tuberculosis UDP + alpha,alpha-trehalose 6-phosphate
-
 ?
UDP-alpha-D-glucose + D-glucose 6-phosphate the enzyme exhibits less activity with UDP-alpha-D-glucose compared to ADP-alpha-D-glucose Mycobacterium tuberculosis H37Rv UDP + alpha,alpha-trehalose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
OtsA
-
 Mycobacterium tuberculosis
Tre-6P Sase
-
 Mycobacterium tuberculosis