BRENDA - Enzyme Database
show all sequences of 2.4.1.347

Allosteric regulation of the partitioning of glucose-1-phosphate between glycogen and trehalose biosynthesis in Mycobacterium tuberculosis

Asencion Diez, M.; Demonte, A.; Syson, K.; Arias, D.; Gorelik, A.; Guerrero, S.; Bornemann, S.; Iglesias, A.; Biochim. Biophys. Acta 1850, 13-21 (2015)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
fructose-6-phosphate
the activity of the enzyme is increased up to 2fold by fructose-6-phosphate
Mycobacterium tuberculosis
Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ADP-alpha-D-glucose + D-glucose 6-phosphate
Mycobacterium tuberculosis
-
ADP + alpha,alpha-trehalose 6-phosphate
-
-
?
ADP-alpha-D-glucose + D-glucose 6-phosphate
Mycobacterium tuberculosis H37Rv
-
ADP + alpha,alpha-trehalose 6-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-
Purification (Commentary)
Commentary
Organism
HisTrap column chromatography
Mycobacterium tuberculosis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ADP-alpha-D-glucose + D-glucose 6-phosphate
-
741972
Mycobacterium tuberculosis
ADP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
ADP-alpha-D-glucose + D-glucose 6-phosphate
-
741972
Mycobacterium tuberculosis H37Rv
ADP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
the enzyme exhibits less activity with UDP-alpha-D-glucose compared to ADP-alpha-D-glucose
741972
Mycobacterium tuberculosis
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
the enzyme exhibits less activity with UDP-alpha-D-glucose compared to ADP-alpha-D-glucose
741972
Mycobacterium tuberculosis H37Rv
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
fructose-6-phosphate
the activity of the enzyme is increased up to 2fold by fructose-6-phosphate
Mycobacterium tuberculosis
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ADP-alpha-D-glucose + D-glucose 6-phosphate
Mycobacterium tuberculosis
-
ADP + alpha,alpha-trehalose 6-phosphate
-
-
?
ADP-alpha-D-glucose + D-glucose 6-phosphate
Mycobacterium tuberculosis H37Rv
-
ADP + alpha,alpha-trehalose 6-phosphate
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
HisTrap column chromatography
Mycobacterium tuberculosis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ADP-alpha-D-glucose + D-glucose 6-phosphate
-
741972
Mycobacterium tuberculosis
ADP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
ADP-alpha-D-glucose + D-glucose 6-phosphate
-
741972
Mycobacterium tuberculosis H37Rv
ADP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
the enzyme exhibits less activity with UDP-alpha-D-glucose compared to ADP-alpha-D-glucose
741972
Mycobacterium tuberculosis
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
the enzyme exhibits less activity with UDP-alpha-D-glucose compared to ADP-alpha-D-glucose
741972
Mycobacterium tuberculosis H37Rv
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
Other publictions for EC 2.4.1.347
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741972
Asencion Diez
Allosteric regulation of the ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biochim. Biophys. Acta
1850
13-21
2015
1
-
1
-
-
-
-
-
-
-
-
2
-
160
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687429
Nobre
A unique combination of geneti ...
Rubrobacter xylanophilus
J. Bacteriol.
190
7939-7946
2008
-
-
-
-
-
-
-
2
-
1
1
-
-
1
-
-
-
-
-
-
-
-
1
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
1
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
675853
Cardoso
Biochemical and genetic charac ...
Propionibacterium freudenreichii
Microbiology
153
270-280
2007
1
-
1
-
-
-
2
8
-
3
-
1
-
1
-
-
1
-
-
-
-
-
5
-
1
-
-
-
2
1
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
8
-
3
-
1
-
-
-
1
-
-
-
-
5
-
1
-
-
-
2
1
-
-
-
-
-
-
-
-
488618
Pan
Trehalose-phosphate synthase o ...
Mycobacterium tuberculosis
Eur. J. Biochem.
269
6091-6100
2002
1
-
1
-
-
-
-
3
-
-
2
1
-
1
-
-
1
-
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
3
-
-
2
1
-
-
-
1
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742432
Pan
Trehalose-phosphate synthase ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Eur. J. Biochem.
269
6091-6100
2002
-
-
1
-
-
-
-
4
-
1
-
-
-
2
-
-
1
-
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
1
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741948
Ferreira
Trehalose accumulation in mut ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1335
40-50
1997
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-