Literature summary for 2.4.1.34 extracted from

Loiko, V.; Wagener, J.
The paradoxical effect of echinocandins in Aspergillus fumigatus relies on recovery of the beta-1,3-glucan synthase Fks1 (2017), Antimicrob. Agents Chemother., 61, e01690 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
caspofungin	very high caspofungin concentrations exert an additional antifungal activity besides inhibition of the beta-1,3-glucan synthase. Exposure to inhibitory caspofungin concentrations causes initial growth deprivation independently of the capability of the drug concentration to induce the paradoxical effect, i.e. the resumption of growth of otherwise susceptible strains at higher drug concentrations. Paradoxically growing hyphae emerge from microcolonies essentially devoid of beta-1,3-glucan. These hyphae expose beta-1,3-glucan again, suggesting that beta-1,3-glucan synthesis is restored. Expression of the beta-1,3-glucan synthase Fks1 is an essential requirement for the paradoxical effect. Overexpression of Fks1 renders Emericella nidulans more susceptible, whereas reduced expression leads to hyphae that are more resistant to the growth-inhibitory and limited fungicidal activity of caspofungin	Aspergillus fumigatus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	-	-	-
Aspergillus fumigatus AfS35	-	-	-

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Release 2023.1 (January 2023)