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Information on EC 2.4.1.34 - 1,3-beta-glucan synthase
for references in articles please use BRENDA:EC2.4.1.34
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.34 1,3-beta-glucan synthase
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 2.4.1.34
- candida
-
echinocandins
- albicans
- caspofungin
-
cytokinesis
- micafungin
- amphotericin
- candidiasis
- rho1
- anidulafungin
-
powdery
-
plasmodesmata
- mildew
- pneumocandins
- microspore
- papulacandins
-
calcofluor
- symplastic
-
candidemia
-
aculeacin
-
echinocandin-resistant
- agriculture
- analysis
- medicine
Reaction Schemes
showSynonyms
callose synthase, fks1p, beta-1,3-glucan synthase, 1,3-beta-glucan synthase, 1,3-beta-d-glucan synthase, beta-glucan synthase, bgs1p, (1,3)-beta-d-glucan synthase, bgs4p, glucan synthase-like, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(1,3)-beta-D-glucan synthase
(1,3)-beta-glucan (callose) synthase
-
-
-
-
1,3-beta-D-glucan 3-beta-D-glucosyltransferase
1,3-beta-D-glucan synthase
1,3-beta-D-glucan synthetase
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-
-
-
1,3-beta-D-glucan-UDP glucosyltransferase
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-
-
-
1,3-beta-glucan synthase
1,3-beta-glucan-uridine diphosphoglucosyltransferase
-
-
-
-
beta(1,3)-D-glucan synthase
beta(1,3)glucan synthase
beta-1,3-glucan synthase
beta-1,3-glucan synthetase
-
-
-
-
beta-glucan synthase
callose synthase
callose synthetase
-
-
-
-
CalS
CrdS
curdlan synthase
Fks
FKS2
GCS1
GS-II
-
-
-
-
Gsc-1
Gsc1
GSC2
GSL
paramylon synthetase
-
-
-
-
PNEG_03180
PNEJI1_001061
UDP-glucose-1,3-beta-glucan glucosyltransferase
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-
-
-
UDP-glucose-beta-glucan glucosyltransferase
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-
-
-
UDP-glucose:(1,3)beta-glucan synthase
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-
-
-
UDPglucose-1,3-beta-D-glucan glucosyltransferase
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-
-
-
uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase
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-
-
-
ZT1E4_G10604
additional information
1,3-beta-D-glucan synthase
-
-
-
-
beta(1,3)glucan synthase
-
complex composed of at least two proteins, Rho1p and Fks1p
beta-1,3-glucan synthase
-
-
-
-
callose synthase
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-
-
-
additional information
the enzyme belongs to the (1,3)-beta-D-glucan synthase gene family of Hordeum vulgare
additional information
the enzyme belongs to the (1,3)-beta-D-glucan synthase gene family of Hordeum vulgare
additional information
the enzyme belongs to the (1,3)-beta-D-glucan synthase gene family of Hordeum vulgare
additional information
the enzyme belongs to the (1,3)-beta-D-glucan synthase gene family of Hordeum vulgare
additional information
the enzyme belongs to the (1,3)-beta-D-glucan synthase gene family of Hordeum vulgare
additional information
the enzyme belongs to the (1,3)-beta-D-glucan synthase gene family of Hordeum vulgare
additional information
-
the enzyme belongs to the PpCalS callose synthase gene family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1
-
-
-
-
UDP-alpha-D-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1
model of donor-binding region
-
UDP-alpha-D-glucose + [(1->3)-beta-D-glucosyl]n = UDP + [(1->3)-beta-D-glucosyl]n+1
model of donor-binding region
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
hexosyl group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:(1->3)-beta-D-glucan 3-beta-D-glucosyltransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
9037-30-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-glucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1-3)-beta-D-glucosyl]n
UDP + [(1-3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1-3)-beta-D-glucosyl]n
UDP + [(1-3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: specific for UDPglucose as glucosyl donor
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: synthesis of callose in higher plants, enzyme is latent in intact and undamaged cells, it is activated only under perturbed conditions, possible involvement in wound-healing process and in defense against pathogens, enzyme seems to play a vital role in a number of specialized developmental processes in plants, namely pollen maturation and sieve pore formation and gravitropism
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: chain length 60-80
Products: chain length 60-80
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: production of cell wall polysaccharide found in yeast cells
Products: chain length 60-80
Products: chain length 60-80
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: main biosynthetic enzyme responsible for the callose response to biotic, abiotic, and chemical stresses, but not for callose deposition that is part of normal cell development. Enzyme negatively regulates salicylic acid defense signaling pathway
Products: -
Products: -
?
additional information
?
-
-
Substrates: cell wall biosynthetic enzyme
Products: -
Products: -
?
additional information
?
-
-
Substrates: 1,3-beta-D-glucan synthase catalyses the synthesis of 1,3-beta-D-glucan, the most abundant component of the fungal cell wall.
Products: -
Products: -
?
additional information
?
-
-
Substrates: the recombinant cytoplasmic domain binds specifically to UDP-agarose and lichenan (beta-glucan), but not to ADP-agarose, GDP-agarose, or other carbohydrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: cell wall biosynthetic enzyme
Products: -
Products: -
?
additional information
?
-
-
Substrates: simple and sensitive method for characterization of enzyme products by analysis of newly synthesized polysaccharides by 13C-nuclear magnetic resonance
Products: -
Products: -
?
additional information
?
-
Substrates: the purified yeast glucan synthase produces glucan with a length of 6550 plus/minus 760 mer. Pre-steady state kinetics analysis reveal a highly efficient but rate-determining chain elongation rate of 51.5 per s
Products: -
Products: -
-
additional information
?
-
Substrates: the purified yeast glucan synthase produces glucan with a length of 6550 plus/minus 760 mer. Pre-steady state kinetics analysis reveal a highly efficient but rate-determining chain elongation rate of 51.5 per s
Products: -
Products: -
-
additional information
?
-
Substrates: involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
Products: -
Products: -
?
additional information
?
-
-
Substrates: involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
Products: -
Products: -
?
additional information
?
-
-
Substrates: bgs2p synthesizes linear beta-1,3-glucans, which remain unorganized and alkali-soluble untilcovalent linkages are set up between beta-1,3-glucans and other cell wall components involving beta-1,3-glucanosyltransferase activity, overview, bgs2p localizes to the spore periphery and is essential for maturation of the ascospore wall
Products: -
Products: -
?
additional information
?
-
-
Substrates: linear (1,3)beta-D-glucan is the polysaccharide that specifically interacts with the fluorochrome Calcofluor white in fission yeast, the (1,3)beta-D-glucan synthase subunit Bgs1p is responsible for the fission yeast primary septum formation, Bgs1p is essential for vegetative cells and needed for correct septation and cell separation
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1,3)-beta-D-glucosyl]n
UDP + [(1,3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
-
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDP-glucose + [(1->3)-beta-D-glucosyl]n
UDP + [(1->3)-beta-D-glucosyl]n+1
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: synthesis of callose in higher plants, enzyme is latent in intact and undamaged cells, it is activated only under perturbed conditions, possible involvement in wound-healing process and in defense against pathogens, enzyme seems to play a vital role in a number of specialized developmental processes in plants, namely pollen maturation and sieve pore formation and gravitropism
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: production of cell wall polysaccharide found in yeast cells
Products: chain length 60-80
Products: chain length 60-80
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: main biosynthetic enzyme responsible for the callose response to biotic, abiotic, and chemical stresses, but not for callose deposition that is part of normal cell development. Enzyme negatively regulates salicylic acid defense signaling pathway
Products: -
Products: -
?
additional information
?
-
-
Substrates: cell wall biosynthetic enzyme
Products: -
Products: -
?
additional information
?
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Substrates: the recombinant cytoplasmic domain binds specifically to UDP-agarose and lichenan (beta-glucan), but not to ADP-agarose, GDP-agarose, or other carbohydrates
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Substrates: cell wall biosynthetic enzyme
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Substrates: involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
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Substrates: involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
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Substrates: bgs2p synthesizes linear beta-1,3-glucans, which remain unorganized and alkali-soluble untilcovalent linkages are set up between beta-1,3-glucans and other cell wall components involving beta-1,3-glucanosyltransferase activity, overview, bgs2p localizes to the spore periphery and is essential for maturation of the ascospore wall
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Substrates: linear (1,3)beta-D-glucan is the polysaccharide that specifically interacts with the fluorochrome Calcofluor white in fission yeast, the (1,3)beta-D-glucan synthase subunit Bgs1p is responsible for the fission yeast primary septum formation, Bgs1p is essential for vegetative cells and needed for correct septation and cell separation
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
Mn2+
Ca2+
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stimulates at low concentration, inhibits at high concentrations
Mg2+
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15 mM MgCl2 stimulates at 0.01 mM UDPglucose, decreases at 1 mM UDPglucose
Mn2+
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stimulates at low concentrations, inhibits at high concentrations
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(1R,3R,6aS,7R,8R,10bR,12aR)-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-3-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
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IC50: 19 ng/ml, pH and temperature not specified in the publication
(1R,3R,6aS,7R,8R,10bR,12aR)-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-2-[[(2R)-2-methylpyrrolidin-2-yl]methoxy]-3-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
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IC50: 4 ng/ml, pH and temperature not specified in the publication
(1R,3R,6aS,7R,8R,10bR,12aR)-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-3-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
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IC50: 61 ng/ml, pH and temperature not specified in the publication
(1R,3R,6aS,7R,8R,10bR,12aR)-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-3-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-2-[(2R)-pyrrolidin-2-ylmethoxy]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
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IC50: 22 ng/ml, pH and temperature not specified in the publication
(1R,3R,6aS,7R,8R,10bR,12aR)-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-3-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-2-[(2S)-pyrrolidin-2-ylmethoxy]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
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IC50: 18 ng/ml, pH and temperature not specified in the publication
(1R,3R,6aS,7R,8R,10bR,12aR)-2-[[(2R)-1,2-dimethylpyrrolidin-2-yl]methoxy]-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-3-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
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IC50: 6.4 ng/ml, pH and temperature not specified in the publication
(1R,6aS,7R,8R,10bR,12aR)-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-3-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-2-[[(2R)-2,3,3-trimethyl-2-(methylamino)butyl]oxy]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid
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IC50: 2 ng/ml, pH and temperature not specified in the publication
(2,6-difluoro-phenyl)-carbamic acid 3-(4-benzothiazol-2-yl-piperazine-1-yl)-propyl ester
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The piperazine propanol derivative GS1578 was identified as a potent inhibitor against 1,3-beta-D-glucan synthase, IC50: 0.16 microM.
Acylcarnitine
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inhibition in presence of digitonin, stimulation in absence of digitonin within a certain concentration range
anidulafungin
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an antifungal echinocandin drug, inhibition profile of wild-type and mutant enzymes
EGTA