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Literature summary for 2.4.1.34 extracted from
- Caspofungin-mediated growth inhibition and paradoxical growth in Aspergillus fumigatus involve fungicidal hyphal tip lysis coupled with regenerative intrahyphal growth and dynamic changes in beta-1,3-glucan synthase localization (2017), Antimicrob. Agents Chemother., 61, e00710 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| caspofungin | treatment with caspofungin at either the growth-inhibitory concentration (0.5 microg/ml) or paradoxical growth-inducing concentration (4 microg/ml) for 24 h causes similar abnormalities, including wider, hyperbranched hyphae, increased septation, and repeated hyphal tip lysis, followed by regenerative intrahyphal growth. At both concentrations, Fks1 initially mislocalizes from the hyphal tips to vacuoles. Only continuous exposure to 4 microg/ml of caspofungin for 48 h leads to recovery of the normal hyphal morphology with renewed localization of Fks1 to hyphal tips. Farnesol blocks paradoxical growth and relocalizes Fks1 and regulatory subunit Rho1 to vacuoles | Aspergillus fumigatus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| vacuole | - |
Aspergillus fumigatus | 5773 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus fumigatus | P87204 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Fks | - |
Aspergillus fumigatus |
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