Literature summary for 2.4.1.255 extracted from

Xing, L.; Liu, Y.; Xu, S.; Xiao, J.; Wang, B.; Deng, H.; Lu, Z.; Xu, Y.; Chong, K.
Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering (2018), EMBO J., 37, e98115 .

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Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q9M8Y0	-	-

Synonyms

Synonyms	Comment	Organism
O-GlcNAc transferase	-	Arabidopsis thaliana
Protein SECRET AGENT	-	Arabidopsis thaliana
SEC	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
malfunction	loss of function of SECRET AGENT, leads to an early flowering phenotype. This results from reduced histone H3 lysine 4 trimethylation (H3K4me3) of FLOWERING LOCUS C (FLC) locus, which encodes a key negative regulator of flowering	Arabidopsis thaliana
physiological function	the enzyme catalyzes the post-translational modification of proteins. the enzyme (SEC) activates ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1), a histone lysine methyltransferase (HKMT), through O-GlcNAc modification to augment ATX1-mediated H3K4me3 histone modification at FLC locus. SEC transfers an O-GlcNAc group on Ser947 of ATX1, which resides in the SET domain, thereby activating ATX1	Arabidopsis thaliana

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Release 2023.1 (January 2023)