Literature summary for 2.4.1.227 extracted from

Mann, P.A.; Mueller, A.; Xiao, L.; Pereira, P.M.; Yang, C.; Ho Lee, S.; Wang, H.; Trzeciak, J.; Schneeweis, J.; Dos Santos, M.M.; Murgolo, N.; She, X.; Gill, C.; Balibar, C.J.; Labroli, M.; Su, J.; Flattery, A.; Sherborne, B.; Maier, R.; Tan, C.M.; Black, T.; Onder, K.; Kargman, S.; Monsma, F.J.; Pinho, M.G.; Schneider, T.; Roemer, T.
Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG (2013), ACS Chem. Biol., 8, 2442-2451.

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	beta-lactam potentiation screening to identify small molecules that augment the activity of beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA), mechanistic characterization of a compound termed murgocil. Chemical synergy and cidality is achieved between murgocil and the beta-lactam imipenem mediated through MurG-dependent localization of penicillin-binding protein PBP2 to the division septum	Staphylococcus aureus
murgocil	a highly bioactive staphylococcal-specific inhibitor of intracellular membrane-associated enzyme MurG	Staphylococcus aureus

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	intracellular membrane-associated	Staphylococcus aureus	16020	-

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	methicillin-resistant	-

Synonyms	Comment	Organism
MurG	-	Staphylococcus aureus
peptidoglycan glycosyltransferase	-	Staphylococcus aureus

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Release 2023.1 (January 2023)