Literature summary for 2.4.1.221 extracted from

McMillan, B.J.; Zimmerman, B.; Egan, E.D.; Lofgren, M.; Xu, X.; Hesser, A.; Blacklow, S.C.
Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations (2017), Glycobiology, 27, 777-786 .

Search for more literature for 2.4.1.221

Application

Application	Comment	Organism
drug development	POFUT1 is a potential target for cancers driven by Notch1 mutations	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
vapor diffusion using the hanging drop method. Structures of the enzyme (POFUT1) in free and GDP-fucose bound states	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9H488	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
U2-OS cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Pofut1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	CRISPR-mediated knockout of POFUT1 in U2OS cells suppresses both normal Notch1 signaling, and the ligand-independent signaling associated with leukemogenic mutations of Notch1. Normal and oncogenic signaling are rescued by wild-type POFUT1 but rescue is impaired by an active-site R240A mutation	Homo sapiens

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Release 2023.1 (January 2023)