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Literature summary for 2.4.1.221 extracted from

  • Holdener, B.C.; Haltiwanger, R.S.
    Protein O-fucosylation structure and function (2019), Curr. Opin. Struct. Biol., 56, 78-86 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.221

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
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 Homo sapiens 5783
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H488
-
-
Homo sapiens Q9Y2G5
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information fucose is added exclusively to properly folded Epidermal Growth Factor-like (EGF) repeats and Thrombospondin Type 1 Repeats (TSRs) Homo sapiens ?
-
-
additional information fucose is added exclusively to properly folded Epidermal Growth Factor-like (EGF) repeats and Thrombospondin Type 1 Repeats (TSRs). The O-linked fucose can also be elongated with other sugars Homo sapiens ?
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Synonyms

Synonyms Comment Organism
Pofut1
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 Homo sapiens
POFUT2
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 Homo sapiens
protein O-fucosyltransferases 1
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 Homo sapiens
protein O-fucosyltransferases 2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction heterozygous mutations in POFUT1 are linked to a rare skin condition, Dowling-Degos Disease. Amplification of POFUT1 is associated with several types of cancer Homo sapiens
physiological function both POFUT1 and POFUT2 are proposed to participate in non-canonical endoplasmic reticulum quality control pathways for the folding of Epidermal Growth Factor-like (EGF) repeats and Thrombospondin Type 1 Repeats (TSRs), respectively Homo sapiens
physiological function both POFUT1 and POFUT2 participate in non-canonical endoplasmic reticulum quality control pathways for the folding of Epidermal Growth Factor-like (EGF) repeats and Thrombospondin Type 1 Repeats (TSRs), respectively Homo sapiens