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Literature summary for 2.4.1.17 extracted from

  • Yuan, L.M.; Gao, Z.Z.; Sun, H.Y.; Qian, S.N.; Xiao, Y.S.; Sun, L.L.; Zeng, S.
    Inter-isoform hetero-dimerization of human UDP-glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and impacts on glucuronidation activity (2016), Sci. Rep., 6, 34450 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
expressed in in Sf9 insect cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60656
-
-
Homo sapiens P16662
-
-
Homo sapiens P22309
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 quercetin + 3 UDP-glucuronate isoform UGT1A9 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 3-glucuronide, and 3'-glucuronide Homo sapiens 3 UDP + quercetin 7-glucuronide + quercetin 3-glucuronide + quercetin 3'-glucuronide
-
 ?
additional information isoform UGT1A1 does not show activity with zidovudine Homo sapiens ?
-
-
additional information isoform UGT1A9 does not show activity with zidovudine Homo sapiens ?
-
-
additional information isoform UGT2B7 is not capable of converting quercetin Homo sapiens ?
-
-
quercetin + UDP-glucuronate isoform UGT1A1 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 4'-glucuronide, and 3'-glucuronide Homo sapiens UDP + quercetin 7-glucuronide + quercetin 4'-glucuronide + quercetin 3'-glucuronide
-
 ?
zidovudine + UDP-glucuronate
-
 Homo sapiens UDP + zidovudine O-glucuronide
-
 ?

Subunits

Subunits Comment Organism
heterodimer fluorescence resonance energy transfer technique and co-immunoprecipitation Homo sapiens

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT1A1 isoform Homo sapiens
UGT1A9 isoform Homo sapiens
UGT2B7 isoform Homo sapiens