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Literature summary for 2.4.1.17 extracted from

  • Finel, M.; Li, X.; Gardner-Stephen, D.; Bratton, S.; Mackenzie, P.I.; Radominska-Pandya, A.
    Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity (2005), J. Pharmacol. Exp. Ther., 315, 1143-1149.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
recombinant UGT1A5, expressed in baculovirusinfected insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information replacing the first 110 amino acids of UGT1A5, a region that may be involved in substrate binding, with the counterpart segment from UGT1A4 does not increase the 4-aminobiphenyl glucuronidation activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P35504
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell low-level UGT1A5 expression Homo sapiens
-
Hep-G2 cell low-level UGT1A5 expression Homo sapiens
-
hepatocyte a low basal level of UGT1A5 expression in cultured hepatocytes. Treatment with rifampicin or 3-methylcholanthrene increases the level of UGT1A5 mRNA Homo sapiens
-
intestine UGT1A5 expression in various segments of the intestine, high interindividual variability in its level and distribution along the intestine Homo sapiens
-
liver low-level UGT1A5 expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-hydroxypyrene + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
4-methylumbelliferone + UDP-glucuronate very low rate of glucuronidation Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
 ?
additional information no glucuronidation of 4-aminobiphenyl, a good substrate for the highly homologous enzymes UGT1A4 and UGT1A3 Homo sapiens ?
-
 ?
scopoletin + UDP-glucuronate very low rate of glucuronidation Homo sapiens UDP + scopoletin O-glucuronide
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase 1A5
-
 Homo sapiens