Literature summary for 2.4.1.17 extracted from

  • Krishnaswamy, S.; Hao, Q.; Von Moltke, L.L.; Greenblatt, D.J.; Court, M.H.
    Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6 (2004), Drug Metab. Dispos., 32, 862-869.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of diverse isozymes in a lymphoblast expression system, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-hydroxytryptophol competitive inhibition of serotonin glucuronidation Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.135
-
5-hydroxytryptophol isozyme UGT1A6, pH 7.5, 37°C Homo sapiens
3.674
-
5-hydroxytryptophol isozyme UGT1A9, pH 7.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P19224 isozyme UGT1A6; isozymes UGT1A6 and UGT1A9
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.

Synonyms

Synonyms Comment Organism

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.2
-
5-hydroxytryptophol isozyme UGT1A6, pH 7.5, 37°C Homo sapiens
0.29
-
5-hydroxytryptophol liver microsomes, pH 7.5, 37°C Homo sapiens