Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.16 extracted from

  • Kral, K.; Bieg, T.; Nawrot, U.; W?odarczyk, K.; Lalik, A.; Hahn, P.; Wandzik, I.
    New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase (2015), Bioorg. Chem., 61, 13-20.
    View publication on PubMed
Search for more literature for 2.4.1.16

Inhibitors

Inhibitors Comment Organism Structure
5'-(N-succinyl)-5'-amino-5'-deoxyuridine
-
 Saccharomyces cerevisiae
5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester inhibits the yeast enzyme, and exhibits synergistic interaction with caspofungin against Candida albicans Saccharomyces cerevisiae
5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine
-
 Saccharomyces cerevisiae
5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine methyl ester
-
 Saccharomyces cerevisiae
5'-deoxy-5'-(glycylamino)uridine
-
 Saccharomyces cerevisiae
bis(5'-amino-5'-deoxyuridine) 2,2'-[(1,4-dioxobutane-1,4-diyl)diazanediyl]diacetate 50% inhibition at 3 mM Saccharomyces cerevisiae
bis(5'-amino-5'-deoxyuridine) 4-[(carboxymethyl)amino]-4-oxobutanoate
-
 Saccharomyces cerevisiae
bis(5'-amino-5'-deoxyuridine) succinate
-
 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Saccharomyces cerevisiae UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.8
-
 pH 7.5, 25°C Saccharomyces cerevisiae 5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester