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Literature summary for 2.4.1.11 extracted from
- Purification and properties of the glucose-6-phosphate-dependent form of human placental glycogen synthase (1976), Arch. Biochem. Biophys., 175, 583-589.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| galactose 6-phosphate | 57% of the glucose-6-phosphate activation | Homo sapiens |  |
| glucosamine 6-phosphate | 50% of the glucose-6-phosphate activation | Homo sapiens | |
| glucose 6-phosphate | synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (NH4)2SO4 | 20% inactivation at 20 mM | Homo sapiens | |
| phosphate | Mg2+, Ca2+ or Mn2+ relieves inhibition | Homo sapiens | |
| SO42- | Mg2+, Ca2+ or Mn2+ relieves inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | dependence on glucose 6-phosphate concentration | Homo sapiens | |
| 0.57 | 1.25 | UDP-glucose | value dependent on the presence of glucose 6-phosphate | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activation in presence of glucose 6-phosphate | Homo sapiens | |
| CaSO4 | to a lesser extent, absence of glucose-6-phosphate | Homo sapiens | |
| CoSO4 | absence of glucose-6-phosphate | Homo sapiens | |
| FeSO4 | to a lesser extent, absence of glucose-6-phosphate | Homo sapiens | |
| KCl | activation in presence of glucose 6-phosphate | Homo sapiens | |
| Mg2+ | activation in presence of glucose 6-phosphate | Homo sapiens | |
| MgSO4 | to a lesser extent, absence of glucose-6-phosphate | Homo sapiens | |
| Mn2+ | activation in presence of glucose 6-phosphate | Homo sapiens | |
| MnSO4 | absence of glucose-6-phosphate | Homo sapiens | |
| NaCl | activation in presence of glucose 6-phosphate | Homo sapiens | |
| NH4Cl | activation in presence of glucose 6-phosphate | Homo sapiens | |
| NiSO4 | absence of glucose-6-phosphate | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | Homo sapiens | - |
glycogen + UDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | interconversion of D form to I form is Mn2+ dependent | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 14.13 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 45 mM Tris/HCl buffer, pH 7.5, 1 mM DTT, 10% glycerol, several months | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | - |
Homo sapiens | glycogen + UDP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9.2 | synthase D, presence of glucose 6-phosphate | Homo sapiens |
| 7 | 8.5 | synthase D, absence of glucose 6-phosphate | Homo sapiens |
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