BRENDA - Enzyme Database
show all sequences of 2.4.1.109

Protein C-mannosylation is enzyme-catalysed and uses dolichyl-phosphate-mannose as a precursor

Doucey, M.A.; Hess, D.; Cacan, R.; Hofsteenge, J.; Mol. Biol. Cell 9, 291-300 (1998)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
chymotrypsin
inactivation
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Rattus norvegicus
16020
-
microsome
-
Rattus norvegicus
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dolichyl phosphate D-mannose + ribonuclease 2
Rattus norvegicus
C-mannosylation activity
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
dolichyl phosphate D-mannose + ribonuclease 2
Rattus norvegicus
biosynthetic pathway
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
C-mannosylating enzyme
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dolichyl phosphate D-mannose + human ribonuclease 2
whole protein or N-terminal dodecapeptide containing Trp7
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + human ribonuclease 2
C-mannosylation activity
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + human ribonuclease 2
no C-mannosylation activity of Trp7 when Trp10 is exchanged for Ala in the acceptor substrate
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + human ribonuclease 2
recombinant wild-type RNase from E. coli is no substrate
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + ribonuclease 2
C-mannosylation activity
638341
Rattus norvegicus
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
-
dolichyl phosphate D-mannose + ribonuclease 2
C-mannosylation activity
638341
Rattus norvegicus
dolichyl phosphate + ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + ribonuclease 2
biosynthetic pathway
638341
Rattus norvegicus
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
26
-
about
Rattus norvegicus
37
-
assay at
Rattus norvegicus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
26
-
22 h, stable
Rattus norvegicus
37
-
60 min, stable
Rattus norvegicus
95
-
inactivation
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
chymotrypsin
inactivation
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Rattus norvegicus
16020
-
microsome
-
Rattus norvegicus
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dolichyl phosphate D-mannose + ribonuclease 2
Rattus norvegicus
C-mannosylation activity
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
dolichyl phosphate D-mannose + ribonuclease 2
Rattus norvegicus
biosynthetic pathway
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dolichyl phosphate D-mannose + human ribonuclease 2
whole protein or N-terminal dodecapeptide containing Trp7
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + human ribonuclease 2
C-mannosylation activity
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + human ribonuclease 2
no C-mannosylation activity of Trp7 when Trp10 is exchanged for Ala in the acceptor substrate
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + human ribonuclease 2
recombinant wild-type RNase from E. coli is no substrate
638341
Rattus norvegicus
dolichyl phosphate + human ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + ribonuclease 2
C-mannosylation activity
638341
Rattus norvegicus
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
-
dolichyl phosphate D-mannose + ribonuclease 2
C-mannosylation activity
638341
Rattus norvegicus
dolichyl phosphate + ribonuclease 2-D-mannose
D-mannose is bound at Trp7 forming a C-C linkage
638341
Rattus norvegicus
?
dolichyl phosphate D-mannose + ribonuclease 2
biosynthetic pathway
638341
Rattus norvegicus
dolichyl phosphate + ribonuclease 2-D-mannose
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
26
-
about
Rattus norvegicus
37
-
assay at
Rattus norvegicus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
26
-
22 h, stable
Rattus norvegicus
37
-
60 min, stable
Rattus norvegicus
95
-
inactivation
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Rattus norvegicus
Other publictions for EC 2.4.1.109
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736741
Loibl
Photoaffinity labeling of prot ...
Saccharomyces cerevisiae
Methods Mol. Biol.
1022
107-117
2013
-
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1
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2
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3
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1
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1
1
1
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1
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1
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2
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1
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1
1
1
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1
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2
2
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-
737115
Nett
Characterization of the Pichia ...
Komagataella pastoris, Komagataella pastoris GS115
PLoS ONE
8
e68325
2013
-
-
1
-
1
-
5
-
1
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-
-
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4
-
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-
-
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2
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2
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6
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2
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-
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-
-
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3
6
-
-
-
721498
Akasaka-Manya
Different roles of the two com ...
Homo sapiens
Biochem. Biophys. Res. Commun.
411
721-725
2011
-
-
1
-
6
-
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-
1
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3
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1
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1
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1
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6
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1
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1
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1
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1
1
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722731
Lommel
A conserved acidic motif is cr ...
Homo sapiens
J. Biol. Chem.
286
39768-39775
2011
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-
-
-
19
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2
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1
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4
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4
1
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19
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4
1
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722860
Goder
Protein O-mannosyltransferases ...
Saccharomyces cerevisiae
J. Cell Sci.
124
144-153
2011
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1
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3
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1
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1
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1
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1
1
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708616
Nakamura
Drosophila Dystroglycan is a t ...
Drosophila melanogaster
Glycobiology
20
381-394
2010
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1
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2
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1
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1
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4
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2
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1
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1
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2
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1
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1
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2
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1
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2
2
-
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-
710090
Lommel
Correlation of enzyme activity ...
Homo sapiens
Neurology
74
157-164
2010
-
1
1
-
2
-
-
-
-
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3
-
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2
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2
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1
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1
1
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2
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3
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2
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1
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1
1
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710329
Fernandez-Alvarez
The requirement for protein O- ...
Ustilago maydis
Plant Signal. Behav.
5
0000
2010
-
-
-
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1
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4
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2
2
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723102
Lommel
POMT1 is essential for protein ...
Mus musculus
Methods Enzymol.
479
323-342
2010
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1
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1
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8
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19
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1
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19
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1
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689201
Snoei
Genetic alterations of protein ...
Homo sapiens
Neuropathology
29
116-124
2009
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4
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708355
Goto
Protein O-mannosyltransferases ...
Aspergillus nidulans
Eukaryot. Cell
8
1465-1474
2009
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1
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1
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2
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2
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2
2
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708356
Kriangkripipat
Aspergillus nidulans protein O ...
Aspergillus nidulans
Eukaryot. Cell
8
1475-1485
2009
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1
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1
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3
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3
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1
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6
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2
6
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708957
Manya
Role of N-glycans in maintaini ...
Homo sapiens
J. Biochem.
147
337-344
2009
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1
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12
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1
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2
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2
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1
1
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1
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1
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1
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12
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1
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1
1
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1
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2
1
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2
2
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710275
Fernandez-Alvarez
The O-mannosyltransferase PMT4 ...
Ustilago maydis
Plant Cell
21
3397-3412
2009
-
1
1
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1
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7
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1
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3
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3
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2
2
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710368
Willger
Characterization of the PMT ge ...
Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. neoformans
PLoS ONE
4
e6321
2009
-
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2
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2
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2
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2
2
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4
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4
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2
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4
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4
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4
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3
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4
3
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4
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4
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4
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2
4
8
4
-
-
684133
Gorka-Niec
Disruption of Trichoderma rees ...
Trichoderma reesei
Acta Biochim. Pol.
55
251-259
2008
-
-
-
-
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1
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1
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5
-
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1
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1
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1
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1
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684584
Kuroda
Efficient antibody production ...
Ogataea minuta
Appl. Environ. Microbiol.
74
446-453
2008
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1
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1
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1
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686027
Lengeler
Protein-O-mannosyltransferases ...
Candida albicans, Cryptococcus neoformans, Mycobacterium tuberculosis, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Cell. Mol. Life Sci.
65
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Protein O-mannosyltransferase ...
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Role of protein O-mannosyltran ...
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O-Mannosyltransferase 1 in Asp ...
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Dystroglycan and protein O-man ...
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Protein O-mannosyltransferase ...
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Characterization of O-mannosyl ...
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Oka
Protein O-mannosyltransferase ...
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Microbiology
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Prill
PMT family of Candida albicans ...
Candida albicans
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Protein O-mannosylation is cru ...
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Agaphonov
Mutation of the protein-O-mann ...
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Arroyo-Flores
Partial purification and chara ...
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Oka
Molecular characterization of ...
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Protein C-mannosylation is enz ...
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Protein-O-glycosylation in yea ...
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Arroyo-Flores
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Biosynthesis of glycoproteins ...
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PMT3 and PMT4, two new members ...
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Yeast
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A new Dol-P-Man:protein O-D-ma ...
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1
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1
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1
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2
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9
2
1
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2
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-
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1
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18
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1
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1
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5
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1
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1
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1
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5
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1
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2
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11
1
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1
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-
-
-
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1
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2
3
1
1
1
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1
1
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2
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11
1
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1
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4
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1
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2
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1
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2
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1
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1
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5
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1
1
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1
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1
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5
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