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Literature summary for 2.3.3.8 extracted from

  • Das, S.; Morvan, F.; Morozzi, G.; Jourde, B.; Minetti, G.C.; Kahle, P.; Rivet, H.; Brebbia, P.; Toussaint, G.; Glass, D.J.; Fornaro, M.
    ATP citrate lyase regulates myofiber differentiation and increases regeneration by altering histone acetylation (2017), Cell Rep., 21, 3003-3011 .
    View publication on PubMed
Search for more literature for 2.3.3.8

Organism

Organism UniProt Comment Textmining
Homo sapiens P53396
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Mus musculus Q91V92
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Source Tissue

Source Tissue Comment Organism Textmining
myoblast primary skeletal muscle-derived myoblast Homo sapiens
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myoblast primary skeletal muscle-derived myoblast Mus musculus
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Synonyms

Synonyms Comment Organism
ACL
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 Homo sapiens
ACL
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 Mus musculus
ATP citrate lyase
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 Homo sapiens
ATP citrate lyase
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 Mus musculus

General Information

General Information Comment Organism
malfunction ATP citrate lyase silencing impairs myoblast and satellite cell differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD Homo sapiens
malfunction ATP citrate lyase silencing impairs myoblast and satellite cell differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD Mus musculus
physiological function ATP citrate lyase plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. The enzyme increases myoblast and satellite cell differentiation in vitro. It increases MYOD expression by acetyl-H3(K9/14/27) enrichment at the MYOD promoter. It acts downstream of IGF-1 to stimulate myogenesis. IT improves muscle regeneration following cardiotoxin-induced injury Homo sapiens
physiological function ATP citrate lyase plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. The enzyme increases myoblast and satellite cell differentiation in vitro. It increases MYOD expression by acetyl-H3(K9/14/27) enrichment at the MYOD promoter. It acts downstream of IGF-1 to stimulate myogenesis. IT improves muscle regeneration following cardiotoxin-induced injury Mus musculus