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Literature summary for 2.3.3.1 extracted from

  • Alhindi, Y.; Vaanholt, L.M.; Al-Tarrah, M.; Gray, S.R.; Speakman, J.R.; Hambly, C.; Alanazi, B.S.; Gabriel, B.M.; Lionikas, A.; Ratkevicius, A.
    Low citrate synthase activity is associated with glucose intolerance and lipotoxicity (2019), J. Nutr. Metab., 2019, 8594825 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Mus musculus 5739
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9CZU6
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-

General Information

General Information Comment Organism
physiological function during high-fat diet feeding, glucose tolerance of mice decreases progressively and to a greater extent in females with low citrate synthase activity compared to wild-type females, with males showing a similar trend. Body weight and fat gain does not differ between low CS activity and wild-type mice. After an 18 h incubation in 0.8 mM palmitate, C2C12 muscle cells with about 50% shRNA-mediated reduction in CS activity show lower viability and increased levels of cleaved caspase-3 compared to the scramble shRNA treated C2C12 cells Mus musculus