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Literature summary for 2.3.2.32 extracted from

  • Duda, D.; Borg, L.; Scott, D.; Hunt, H.; Hammel, M.; Schulman, B.
    Structural insights into NEDD8 activation of Cullin-RING ligases conformational control of conjugation (2008), Cell, 134, 995-1006 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.32

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 2% (w/v) PEG3350, 0.1M HEPES, 0.2 M L-Pro, pH 8.0 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin]-L-lysine Homo sapiens
-
 [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-N6-[NEDD8-protein]-yl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin]-L-lysine
-
 Homo sapiens [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-N6-[NEDD8-protein]-yl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
RBX1
-
 Homo sapiens