Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96B02 | isoform Ube2W | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[ubiquitin-carrier protein Ubc16]-S-ubiquitinyl-L-cysteine + [CHIP]-NH2 | CHIP is a U-box E3 ubiquitin ligase known to interact productively with many E2 enzymes | Homo sapiens | [ubiquitin-carrier protein Ubc16]-L-cysteine + N-terminal-ubiquitinyl-[CHIP] | isoform Ubc16 N-terminally mono-ubiquitinates the ubiquitin E3 ligase CHIP | ? | |
[ubiquitin-carrier protein Ubc16]-S-ubiquitinyl-L-cysteine + [SUMO-2]-NH2 | - |
Homo sapiens | [ubiquitin-carrier protein Ubc16]-L-cysteine + N-terminal-ubiquitinyl-[SUMO-2] | isoform Ubc16 shows specific protein N-terminal monoubiquitylation activity. Ubc16 conjugates ubiquitin not only to its own N-terminus, but also to that of the small ubiquitin-like modifier SUMO in a manner dependent on the SUMO-targeted ubiquitin ligase RNF4, i.e. RING finger protein 4. N-terminal mono-ubiquitylation of SUMO-2 primes it for poly-ubiquitylation by the Ubc13-UEV1 ubiquitin-conjugating enzyme E2 variant 1 heterodimer | ? |
Synonyms | Comment | Organism |
---|---|---|
Ubc16 | - |
Homo sapiens |
UBE2W | - |
Homo sapiens |
ubiquitin-protein ligase W | - |
Homo sapiens |