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Information on EC 2.3.2.25 - N-terminal E2 ubiquitin-conjugating enzyme

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.25 N-terminal E2 ubiquitin-conjugating enzyme
IUBMB Comments
The enzyme ubiquitinylates the N-terminus of the acceptor protein. It is not reactive towards free lysine.
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Word Map
  • 2.3.2.25
  • ubch5a
  • finger
  • polyubiquitination
  • monoubiquitination
  • proteasome-dependent
  • ring-finger
  • autoubiquitination
  • ube2e2
  • isopeptide
  • ubiquitin-specific
  • polyglutamine
  • isg15
  • spinocerebellar
  • ataxin-1
  • cdc34
The enzyme appears in viruses and cellular organisms
Reaction Schemes
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
+
[acceptor protein]-N-terminal-amino acid
=
[E1 ubiquitin-activating enzyme]-L-cysteine
+
N-terminal-ubiquitinyl-[acceptor protein]
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
+
[N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine
=
[E1 ubiquitin-activating enzyme]-L-cysteine
+
S-ubiquitinyl-[N-terminal ubiquitin-conjugating enzyme]-L-cysteine
S-ubiquitinyl-[N-terminal E2 ubiquitin-conjugating E2 enzyme]-L-cysteine
+
[acceptor protein]-N-terminal-amino acid
=
[N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine
+
N-ubiquitinyl-[acceptor protein]-N-terminal amino acid
Synonyms
ubiquitin conjugating enzyme, ubiquitin conjugating enzyme e2, e2 ube2w, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein]
show the reaction diagram
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[N-terminal ubiquitin-conjugating enzyme]-L-cysteine
show the reaction diagram
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S-ubiquitinyl-[N-terminal E2 ubiquitin-conjugating E2 enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine + N-ubiquitinyl-[acceptor protein]-N-terminal amino acid
show the reaction diagram
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-
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