Literature summary for 2.3.1.41 extracted from

Milligan, J.C.; Lee, D.J.; Jackson, D.R.; Schaub, A.J.; Beld, J.; Barajas, J.F.; Hale, J.J.; Luo, R.; Burkart, M.D.; Tsai, S.C.
Molecular basis for interactions between an acyl carrier protein and a ketosynthase (2019), Nat. Chem. Biol., 15, 669-671 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Escherichia coli

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with Escherichia coli acyl-carrier protein, sitting drop vapor diffusion method, using 0.1 M sodium acetate pH 5.4, 0.2 M ammonium acetate, and 20% (w/v) PEG 4000	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]	Escherichia coli	-	a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A953	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA resin column chromatography	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]	-	Escherichia coli	a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	-	?

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl-ACP-synthase I	-	Escherichia coli
FabB	-	Escherichia coli

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Release 2023.1 (January 2023)