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4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
acetyl-CoA + malonyl-CoA
3-oxobutyryl-CoA + CoA
-
-
formation of about 1% triacetic acid lactone
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + CoA
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
acyl-CoA + [acyl-carrier protein]
acyl-[acyl-carrier protein] + CoA
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
butanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
?
-
-
-
?
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
C10-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C12-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C12-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C14-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C14-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C16-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C4-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C6-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
C6-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C8-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate
-
-
?
C8-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
C10-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein
cis-9-hexadecenoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexadecenoyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
decanoyl-ACP + malonyl-ACP
?
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
eicosanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodocosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
isobutyryl-CoA + malonyl-[acyl-carrier protein]
?
malonyl-ACP + lauroyl-ACP
?
-
-
-
-
?
malonyl-ACP + lauroyl-CoA
?
-
-
-
-
?
malonyl-ACP + palmitoyl-ACP
?
-
-
-
-
?
malonyl-ACP + palmitoyl-CoA
?
-
-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
-
decarboxylation reaction
-
-
?
malonyl-CoA + decanoyl-[acyl carrier protein]
?
-
-
-
-
?
malonyl-CoA + lauroyl-ACP
?
-
-
-
-
?
malonyl-CoA + palmitoyl-ACP
?
-
-
-
-
?
malonyl-CoA + palmitoyl-[acyl-carrier protein]
?
-
-
-
-
?
malonyl-phosphopantetheine-14-mer + lauroyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-14-mer + palmitoyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-16-mer + lauroyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-16-mer + palmitoyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-8-mer + lauroyl-ACP
?
-
-
-
-
?
malonyl-phosphopantetheine-8-mer + palmitoyl-ACP
?
-
-
-
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
malonyl-[acyl-carrier protein] + lauroyl-CoA
? + CO2 + [acyl-carrier protein]
-
-
-
-
?
malonyl-[acyl-carrier protein] + myristoyl-CoA
? + CO2 + [acyl-carrier protein]
-
-
-
-
?
malonyl-[acyl-carrier protein] + palmitoyl-CoA
? + CO2 + [acyl-carrier protein]
-
-
-
-
?
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
palmitoyl-[acyl-carrier protein] + malonyl-CoA
3-oxostearoyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
-
?
palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
propionyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketopentanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
stearoyl-[acyl-carrier protein] + malonyl-CoA
3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + CoA
-
only in sheath epidermis
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
additional information
?
-
4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, highly specific for
-
-
?
4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
reaction is part of petroselinic acid biosynthesis, synthase IV
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]

?
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
?
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]

acetoacyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + CoA
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + CoA
synthase III, best substrate
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
ir
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III, recombinant enzyme from E. coli is absolutely specific for
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I
-
-
?
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
synthase III
-
ir
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III
-
-
?
acyl-CoA + [acyl-carrier protein]

acyl-[acyl-carrier protein] + CoA
-
tetradecanoyl-CoA and cis-9-hexadecenoyl-CoA are poor substrates
-
r
acyl-CoA + [acyl-carrier protein]
acyl-[acyl-carrier protein] + CoA
-
catalyzes fatty acyl transfer between CoA and [acyl-carrier-protein], but no direct transfer to the enzyme as with acyl-[acyl-carrier-protein]
-
-
?
acyl-CoA + [acyl-carrier protein]
acyl-[acyl-carrier protein] + CoA
-
catalyzes fatty acyl transfer between CoA and [acyl-carrier-protein], but no direct transfer to the enzyme as with acyl-[acyl-carrier-protein]
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
initiation of fatty acid biosynthesis with acetyl-CoA as a primer, overview substrate specificity
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of unsaturated and saturated fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
responsible for chain elongation during de novo fatty acid synthesis
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
key enzyme for regulation of medium-chain fatty acid synthesis in seeds
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of unsaturated and saturated fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
responsible for chain elongation during de novo fatty acid synthesis
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of mono-unsaturated long-chain fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
part of non-associated fatty acid synthase system of plants and prokaryotes
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
involved in biosynthesis of saturated fatty acids
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
initiation of fatty acid biosynthesis
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
part of fatty acid synthase II
-
-
ir
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
initiation of both straight- and branched-chain fatty acid biosynthesis resulting in a wide variety of produced fatty acids in vivo
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

acyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
acyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
C4 to C14 acyl-[ACP]s, the enzyme readily elongates C4:0-through C10:0-PfACPs, has significantly less activity with C12:0- and C14:0-ACPs, and no capacity for elongation of C16:0-ACP and C18:0-ACP
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]

a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
-
-
?
an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
the endoplasmic reticulum enzyme is involved in synthesis of very long chain fatty acids
-
-
?
an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
KCS-I displays a preference for 20:0-CoA, substrate specificity, overview
-
-
?
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
synthase III
-
-
?
butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III
-
-
?
cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein
-
-
-
-
?
cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein
-
key step in the unsaturated fatty acid, UFA, synthesis pathway. FabB is negatively regulated by the FabR protein
the product is not incorporated into the complex lipids of the bacterium
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate, synthase I
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate, synthase I
-
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, synthase II
-
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, synthase II
-
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate, synthase I
-
-
r
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not cis-vaccenoyl-[acyl-carrier-protein], i.e. cis-11-octenoyl-[acyl-carrier-protein]
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not cis-vaccenoyl-[acyl-carrier-protein], i.e. cis-11-octenoyl-[acyl-carrier-protein]
-
-
r
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates
-
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates
-
-
r
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase IV
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. palmitoyl-[acyl-carrier-protein]
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. palmitoyl-[acyl-carrier-protein]
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
only synthase II, best substrate
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. palmitoyl-[acyl-carrier-protein]
-
-
?
hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
preferred substrate, synthase III
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
r
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
characterization of hexanoyl-enzyme intermediate
-
-
r
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
best substrate, synthase I
-
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]

?
synthase III
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
?
-
synthase III
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
?
-
isobutyryl-CoA is a precursor of branched-chain fatty acid synthesis
-
-
?
malonyl-[acyl-carrier protein]

acetyl-[acyl-carrier protein] + CO2
-
catalyzes malonyl-[acyl-carrier-protein] decarboxylation independent of fatty acyl-[acyl-carrier-protein]
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
-
decarboxylation with 2-3% the rate of beta-ketoacyl-[acyl-carrier-protein]-synthesis
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
-
wild-type synthase I and mutants C163A and C163S
-
?
malonyl-[acyl-carrier protein]
acetyl-[acyl-carrier protein] + CO2
-
-
-
-
?
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I and II
-
-
?
octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
propionyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

beta-ketopentanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
ir
propionyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
beta-ketopentanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
absolutely specific for
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
synthase II, parenchyma and lamina epidermis: palmitoyl-[acyl-carrier-protein] is the only product, sheath epidermis: acyl-[acyl-carrier-protein] up to C22 chain length
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
fatty acid composition of Brassica napus wild-type and transgenic plants overexpressing the E. coli synthase III
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
preference for medium-chain length [acyl-carrier-protein]-substrates, synthase IV
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
ir
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not hexadecanoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not hexadecanoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
specific for acyl-[acyl-carrier-protein] thioesters, not acyl-CoA or acyl pantetheine thioesters
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
specific for acyl-[acyl-carrier-protein] thioesters, not acyl-CoA or acyl pantetheine thioesters
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
fatty acid composition of Brassica napus wild-type and transgenic plants overexpressing the E. coli synthase III
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not octodecanoyl-[acyl-carrier-protein], i.e stearoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
not octodecanoyl-[acyl-carrier-protein], i.e stearoyl-[acyl-carrier-protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
ir
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
substrate specificity, overview
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III, broad specificity
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase III, broad specificity
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
r
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
poor substrate
-
-
r
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
synthase I
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
-
-
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
i.e. myristoyl-[acyl-carrier-protein], only synthase II
-
-
?
additional information

?
-
no substrate: acetyl-[acyl-carrier protein]
-
-
?
additional information
?
-
-
no substrate: acetyl-[acyl-carrier protein]
-
-
?
additional information
?
-
-
synthase III isozymes also utilize iso- and anteiso-branched-chain acyl-CoA primers as substrates
-
-
?
additional information
?
-
the enzyme has a preference for catalyzing the elongation of C4:0 to C14:0 on acyl-carrier protein
-
-
-
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
enzyme also catalyzes a malonyl-CoA-CO2 exchange reaction, overview: substrates and kinetics
-
-
?
additional information
?
-
-
synthase I and II have nearly the same substrate specificity
-
-
?
additional information
?
-
-
enzyme active site structure of wild-type and mutants with or without bound C12 or C8, overview
-
-
?
additional information
?
-
-
synthase I and II have nearly the same substrate specificity
-
-
?
additional information
?
-
-
important role in generation of the lipoic acid precursor octanoyl-acyl-carrier protein
-
-
?
additional information
?
-
-
preference for acyl-[acyl-carrier protein] in decreasing order: C12, C10, C6, C8, C4, C2, C14, C16
-
-
?
additional information
?
-
KAS catalyzes the C2 fatty acid elongation reaction using a Cys-His-His catalytic triad
-
-
?
additional information
?
-
-
KAS catalyzes the C2 fatty acid elongation reaction using a Cys-His-His catalytic triad
-
-
?
additional information
?
-
-
enzyme is able to use Escherichia coli acyl-carrier protein. Enzyme extends longer, physiologically relevant acyl-CoA primers when paired with its native acyl-carrier protein than with Escherichia coli acyl-carrier protein
-
-
?
additional information
?
-
-
synthase I is specific for short-chain fatty acid prolongation while synthase II is active in C18 formation from C16
-
-
?
additional information
?
-
-
rank of activity in decreasing order: isobutyryl-CoA, hexanoyl-CoA, butyryl-CoA, isovaleryl-CoA, acetyl-CoA
-
-
?
additional information
?
-
-
inhibition of FabH leads to loss of accumulation of acetoacetyl-ACP
-
-
?
additional information
?
-
-
FabH produces C14 long-chain beta-ketoacyl-ACP
-
-
?
additional information
?
-
synthase III, FabH, has a preference for straight short-chain CoA primers
-
-
?
additional information
?
-
-
malonyl-CoA-CO2 exchange reaction
-
-
?
additional information
?
-
the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview
-
-
?
additional information
?
-
-
the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview
-
-
?
additional information
?
-
octanoate, the precursor for lipoic acid synthesis, is also produced by the mitochondrial FAS
-
-
?
additional information
?
-
-
octanoate, the precursor for lipoic acid synthesis, is also produced by the mitochondrial FAS
-
-
?
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(5-thiophen-2-ylisoxazol-3-yl)methanol
-
4-phenyl-5-phenylimino-[1,2,4]dithiazolidin-3-one
i.e. HR19; strong, synthase III
5-chloro-4-phenyl-[1,2]-dithiol-3-one
complete inhibition at 0.01 nM, synthase III; i.e. HR12
acyl-CoA
-
at high concentrations
butyryl-CoA
-
synthase III mutants C122Aand C122Q: inhibition of decarboxylation activity in presence of
C75
-
a synthetic inhibitor of fatty acid synthase, inhibits also the beta-ketoacyl synthase, not in simple first order rate reaction, C75 is a competitive, irreversible inhibitor of the overall reaction, the beta-ketoacyl synthase activity and the enoyl reductase activity substrates do not protect the thioesterase activity of rat liver FAS from inactivation by C75, but malonyl-CoA and acetyl-CoA protect the FAS beta-ketoacyl synthase reaction from inactivation by C75 in a competitive manner, overview
genistein
5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
isobutyryl-CoA
-
synthase III mutants C122Aand C122Q: inhibition of decarboxylation activity in presence of
isorhamnetin
3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
N-(3-pyridinyl)-hexanamide
result of an in silicio screening, antimicrobial activity, binding to beta-ketoacyl-[acyl-carrier-protein] synthase I characterized by saturation-transfer difference NMR spectroscopy
p-chloromercuribenzoate
-
complete inhibition at 1 mM
palmitoyl-CoA
-
substrate inhibition above 0.003 mM
thiolactomicin
thiolactomycin is an inhibitor of KAS I and inhibits bacterial cell growth through inhibition of the beta-ketoacyl-ACP synthase activity of type II fatty acids ynthases
Urea
-
about 50% inhibition at 1 M, complete inactivation at 4 M
[Acyl-carrier-protein]
-
wild-type synthase I and mutants, not mutants C163S and K328A, overview
arsenite

-
-
arsenite
-
synthase II and I
cerulenin

-
synthase II, moderate
cerulenin
-
no inhibition
cerulenin
-
analysis of the binding mechanism, mimicks the condensation transition state; FabB: inhibition is irreversible
cerulenin
forms two hydrogen bonding interactions with H333 and backbone amide hydrogen of G391 and a hydrophobic interaction with M197, F229, and F231
cerulenin
irreversible inhibitor of beta-ketoacyl-ACP synthases I and II but is not a selective anti-bacterial because it is also a potent inhibitor of the condensation reaction catalyzed by the mammalian multifunctional (type I) fatty-acidsynthase
cerulenin
-
50% inhibition at 0.2 mM
cerulenin
-
irreversible inhibition, IC50: 0.0158 mM
cerulenin
-
specific inhibition of the enzyme
cerulenin
-
antibiotic, protection by hexanoyl-[acyl-carrier-protein], decanoyl-[acyl-carrier-protein], and tetradecanoyl-[acyl-carrier-protein]
cerulenin
weak, synthase III
cerulenin
-
12-carbon mycotoxin, irreversible inhibition, binding motif; at 0.05 mM: wild-type is completely inactivated, mutant I108F and A193M show only 10% reduced activity
iodoacetamide

-
no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation
iodoacetamide
-
acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect
iodoacetamide
-
after incubation with 2-mercaptethanol
iodoacetamide
-
acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect
iodoacetamide
-
acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect; synthase I and II
N-ethylmaleimide

-
no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation
N-ethylmaleimide
-
no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation
N-ethylmaleimide
-
acyl-[acyl-carrier-protein]-derivatives protect
N-ethylmaleimide
-
after incubation with 2-mercaptoethanol
platencin

-
platencin
-
exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis, targets the two essential proteins, beta-ketoacyl-[acyl carrier protein] synthase II and III, i.e. FabF and FabH, purified FabH IC50: 0.016 mM, overview
platensimycin

-
SB418011

-
-
SB418011
strong, synthase III
thiolactomycin

-
thiolactomycin
-
synthase III
thiolactomycin
-
analysis of the binding mechanism, mimics malonyl-[acyl-carrier-protein]; FabB: inhibition is reversible, competitive
thiolactomycin
forms a hydrogen bonding with H333 and a hydrophobic interaction of Phe229 and Thr300 with ecKAS I
thiolactomycin
-
competitive inhibition, IC50: 0.0236 mM
thiolactomycin
synthase III; weak
thiolactomycin
synthase III; weak
thiolactomycin
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synthase III
additional information

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inhibitor screening of 250000 synthetic compounds, enzyme-inhibitor binding study by NMR spectroscopy, three-dimensional structure of ecKAS I with inhibitors, overview. No or poor inhibition by 2-(2-methylanilino)-N'-[(E)-(6-methylpyridin-2-yl)methylidene]propanehydrazide, (5Z)-5-([4-[(propan-2-yl)oxy]phenyl]methylidene)-3-(prop-2-en-1-yl)-1,3-thiazolidine-2,4-dione, 1-[2-[4-(2-ethoxyethyl)piperazin-1-yl]-2-oxoethyl]pyrrolidin-2-one, 2-(hexylcarbamoyl)cyclohexane-1-carboxylic acid, 2-[(4-methylbenzene-1-sulfonyl)methyl]prop-2-enamide, 2-([(E)-[(3-nitrophenyl)methylidene]amino]oxy)propanoic acid, 2-[4-(furan-2-yl)phenoxy]-2-methylpropanoic acid, and N-(3-pyridinyl) hexanamide, the latter is though active against Staphylococcus aureus and Enterococcus faecalis
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additional information
inhibitor screening of 250000 synthetic compounds, enzyme-inhibitor binding study by NMR spectroscopy, three-dimensional structure of ecKAS I with inhibitors, overview. No or poor inhibition by 2-(2-methylanilino)-N'-[(E)-(6-methylpyridin-2-yl)methylidene]propanehydrazide, (5Z)-5-([4-[(propan-2-yl)oxy]phenyl]methylidene)-3-(prop-2-en-1-yl)-1,3-thiazolidine-2,4-dione, 1-[2-[4-(2-ethoxyethyl)piperazin-1-yl]-2-oxoethyl]pyrrolidin-2-one, 2-(hexylcarbamoyl)cyclohexane-1-carboxylic acid, 2-[(4-methylbenzene-1-sulfonyl)methyl]prop-2-enamide, 2-([(E)-[(3-nitrophenyl)methylidene]amino]oxy)propanoic acid, 2-[4-(furan-2-yl)phenoxy]-2-methylpropanoic acid, and N-(3-pyridinyl) hexanamide, the latter is though active against Staphylococcus aureus and Enterococcus faecalis
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additional information
screening of 50 flavonoids for inhibition potency against the enzyme, in silico molecular docking study, overview. Only genistein and isorhamnetin show inhibition as well as drug likeliness and bioavailability obeying the Lipinski's guidelines of five. No or poor effects by daidzein, luteolin, herbacetin, petunidin, herbacetin, malvidin, casticin, pinocembrin, kaempferol, butin, 7,3',4',5'-tetramethoxyflavanone, sternbin, galangin, dihydrooroxylin, naringenin, hispidulin, prunetin, 3,6-dihydroxyflavone, tricin, hesperetin, dihydroechioidinin 5,7-dihydroxytrimethoxyflavanone, liquiritigenin, diosmetin, isosakuranetin, dihydrowogonin, syringetin, chrysin, cajanin, naringenin trimethyl ether, pectolinarigenin, 3',4',5',5,7-pentamethoxyflavanone, glycitein, tectorigenin, 4'-hydroxy-5,6,7-trimethoxyflavanone, naringenin 5-methyl ether, 6,2',4'-trimethoxyflavanone, naringenin 7,4'-dimethyl ether, 7-hydroxyflavanone, 5,7-dihydroxyisoflavone, onysilin, and biochanin A
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additional information
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screening of 50 flavonoids for inhibition potency against the enzyme, in silico molecular docking study, overview. Only genistein and isorhamnetin show inhibition as well as drug likeliness and bioavailability obeying the Lipinski's guidelines of five. No or poor effects by daidzein, luteolin, herbacetin, petunidin, herbacetin, malvidin, casticin, pinocembrin, kaempferol, butin, 7,3',4',5'-tetramethoxyflavanone, sternbin, galangin, dihydrooroxylin, naringenin, hispidulin, prunetin, 3,6-dihydroxyflavone, tricin, hesperetin, dihydroechioidinin 5,7-dihydroxytrimethoxyflavanone, liquiritigenin, diosmetin, isosakuranetin, dihydrowogonin, syringetin, chrysin, cajanin, naringenin trimethyl ether, pectolinarigenin, 3',4',5',5,7-pentamethoxyflavanone, glycitein, tectorigenin, 4'-hydroxy-5,6,7-trimethoxyflavanone, naringenin 5-methyl ether, 6,2',4'-trimethoxyflavanone, naringenin 7,4'-dimethyl ether, 7-hydroxyflavanone, 5,7-dihydroxyisoflavone, onysilin, and biochanin A
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additional information
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the enzyme shows strong substrate inhibition
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additional information
inhibitor binding structure determination
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additional information
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inhibitor binding structure determination
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additional information
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in vivo inhibition assays, no inhibition by platensimycin
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