Literature summary for 2.3.1.41 extracted from

Jayaraman, M.; Rajendra, S.; Ramadas, K.
Structural insight into conformational dynamics of non-active site mutations in KasA A Mycobacterium tuberculosis target protein (2019), Gene, 720, 144082 .

Search for more literature for 2.3.1.41

Protein Variants

Protein Variants	Comment	Organism
D66N	the non-active site mutation alters the structural stability of the mutant protein structures	Mycobacterium tuberculosis
F413L	the non-active site mutation alters the structural stability of the mutant protein structures	Mycobacterium tuberculosis
G269S	the non-active site mutation alters the structural stability of the mutant protein structures	Mycobacterium tuberculosis
G312S	the non-active site mutation alters the structural stability of the mutant protein structures	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]	Mycobacterium tuberculosis	-	a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	-	?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]	Mycobacterium tuberculosis H37Rv	-	a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WQD9	-	-
Mycobacterium tuberculosis H37Rv	P9WQD9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]	-	Mycobacterium tuberculosis	a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	-	?
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]	-	Mycobacterium tuberculosis H37Rv	a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	-	?

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl ACP synthase I	-	Mycobacterium tuberculosis
Kas A	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)