Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of FAS or ELO enzyme-deficient mutant strains by RNA interference or gene disruption, ACP depletion by RNAi or gene knockout reduces lipoic acid levels and drastically decreases protein lipoylation | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | enzyme in the fatty acid synthase complex | Trypanosoma brucei | - |
- |
mitochondrion | enzyme in the elongase complex | Trypanosoma brucei | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Trypanosoma brucei | the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | Q586W9 | mitochondrial beta-ketoacyl synthase; ssp. brucei, strain 427, procyclic trypanosomes | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Trypanosoma brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview | Trypanosoma brucei | ? | - |
? | |
additional information | octanoate, the precursor for lipoic acid synthesis, is also produced by the mitochondrial FAS | Trypanosoma brucei | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-ACP synthase | - |
Trypanosoma brucei |
elongase | - |
Trypanosoma brucei |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Trypanosoma brucei |