Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.37 extracted from

  • Na, I.; DeForte, S.; Stojanovski, B.M.; Ferreira, G.C.; Uversky, V.N.
    Molecular dynamics analysis of the structural and dynamic properties of the functionally enhanced hepta-variant of mouse 5-aminolevulinate synthase (2018), J. Biomol. Struct. Dyn., 36, 152-165 .
    View publication on PubMed
Search for more literature for 2.3.1.37

Protein Variants

Protein Variants Comment Organism
V501L/Y506R/P510E/R511I/G512N/E513Q/L515K hyperactive mutant Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + glycine Rhodobacter capsulatus
-
 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine Mus musculus
-
 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine Rhodobacter capsulatus ATCC BAA-309
-
 5-aminolevulinate + CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P08680
-
-
Rhodobacter capsulatus P18079
-
-
Rhodobacter capsulatus ATCC BAA-309 P18079
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroid cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + glycine
-
 Rhodobacter capsulatus 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine
-
 Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine
-
 Rhodobacter capsulatus ATCC BAA-309 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Rhodobacter capsulatus
homodimer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
ALAS
-
 Rhodobacter capsulatus
ALAS2
-
 Mus musculus
hemA
-
 Rhodobacter capsulatus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rhodobacter capsulatus
pyridoxal 5'-phosphate
-
 Mus musculus