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Literature summary for 2.3.1.299 extracted from

  • Mullen, T.D.; Jenkins, R.W.; Clarke, C.J.; Bielawski, J.; Hannun, Y.A.; Obeid, L.M.
    Ceramide synthase-dependent ceramide generation and programmed cell death involvement of salvage pathway in regulating postmitochondrial events (2011), J. Biol. Chem., 286, 15929-15942 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.299

Cloned(Commentary)

Cloned (Comment) Organism
gene CERS1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fumonisin B1 inhibits the increase in total cellular ceramide induced by UV-C irradiation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingosine + stearoyl-CoA Homo sapiens
-
 N-stearoylsphingosine + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27544
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast adenocarcinoma cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine + stearoyl-CoA
-
 Homo sapiens N-stearoylsphingosine + CoA
-
 ?

Synonyms

Synonyms Comment Organism
ceramide synthase 1
-
 Homo sapiens
CerS1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens UV-C irradiation increases the CerS1 enzyme expression by 1.27fold up

General Information

General Information Comment Organism
malfunction inhibition of CerS is able to protect from cell death. Moreover, this protection occurs downstream or independently of mitochondrial permeabilization. Inhibition of CerS greatly inhibits plasma membrane permeabilization. Individual CerS knockdown does not significantly inhibit total ceramide accumulation. CerS1 knockdown has minimal effects in untreated cells and fails to prevent the accumulation of any Cer species following irradiation. Inhibition of CerS but not de novo synthesis inhibits plasma membrane rupture that is not specific to UV-C irradiation or MCF-7 cells Homo sapiens
metabolism regulation of sphingolipid metabolism by UV-C irradiation, overview. Ceramide species that are the least abundant (e.g. C18-Cer, C18:1-Cer, C20-Cer, C22:1-Cer, etc.) exhibit the greatest fold increases. More abundant ceramide species (e.g. C16-Cer, C24-Cer, and C24:1-Cer) show more modest fold changes, although they account for much more of the overall increase in ceramides Homo sapiens
physiological function sphingolipid ceramides are widely implicated in the regulation of programmed cell death or apoptosis. CerS1 regulates C18:0-Cer synthesis Homo sapiens