Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.297 extracted from

  • Kim, Y.R.; Volpert, G.; Shin, K.O.; Kim, S.Y.; Shin, S.H.; Lee, Y.; Sung, S.H.; Lee, Y.M.; Ahn, J.H.; Pewzner-Jung, Y.; Park, W.J.; Futerman, A.H.; Park, J.W.
    Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability (2017), J. Cell. Mol. Med., 21, 3565-3578 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.297

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a very-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 a very-long-chain ceramide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a very-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus a very-long-chain ceramide + CoA
-
 ?

Synonyms

Synonyms Comment Organism
ceramide synthase 2
-
 Mus musculus
CerS2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ceramide synthase 2 null mice are more susceptible to dextran sodium sulfate-induced colitis, and their survival rate is markedly decreased compared with that of wild type littermates. In the colon of enzyme-deficient mice, the expression of junctional adhesion molecule-A is markedly decreased and the phosphorylation of myosin light chain 2 is increased. Enzyme deficiency influences intestinal barrier function and the severity of experimental colitis Mus musculus