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Information on EC 2.3.1.297 - very-long-chain ceramide synthase

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IUBMB Comments
This entry describes ceramide synthase enzymes that are specific for very-long-chain fatty acyl-CoA substrates. The two isoforms from yeast and the plant LOH1 and LOH3 isoforms transfer 24:0 and 26:0 acyl chains preferentially and use phytosphingosine as the preferred sphingoid base. The mammalian CERS2 isoform is specific for acyl donors of 20-26 carbons, which can be saturated or unsaturated. The mammalian CERS3 isoform catalyses this activity, but has a broader substrate range and also catalyses the activity of EC 2.3.1.298, ultra-long-chain ceramide synthase. Both mammalian enzymes can use multiple sphingoid bases, including sphinganine, sphingosine, and phytosphingosine.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
a very-long-chain fatty acyl-CoA
+
=
a very-long-chain ceramide
+
Synonyms
(dihydro)ceramide synthase, acyl-CoA : sphingosine N-acyltramferase, acyl-CoA ceramide synthase, ceramide synthase, ceramide synthase 2, ceramide synthase 3, ceramide synthase 4, ceramide synthase complex, ceramide synthetase, CerS2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a very-long-chain fatty acyl-CoA + a sphingoid base = a very-long-chain ceramide + CoA
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PATHWAY SOURCE
PATHWAYS
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