Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.297 extracted from

  • Ferreira, N.S.; Engelsby, H.; Neess, D.; Kelly, S.L.; Volpert, G.; Merrill, A.H.; Futerman, A.H.; Faergeman, N.J.
    Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein (2017), J. Biol. Chem., 292, 7588-7597 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.297

Activating Compound

Activating Compound Comment Organism Structure
acyl-coenzyme A-binding protein increases the activity of ceramide synthase 2 by more than 2fold. The compound binds very-long chain acyl-CoA esters, which is required for its ability to stimulate enzyme activity Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a very-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 a very-long-chain ceramide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a very-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus a very-long-chain ceramide + CoA
-
 ?
nervonyl-CoA + sphinganine
-
 Mus musculus CoA + nervonyl-sphinganine
-
 ?

Synonyms

Synonyms Comment Organism
ceramide synthase 2
-
 Mus musculus
CerS2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ceramide synthase 2 activity is significantly reduced in the testes of acyl-coenzyme A-binding protein-deficient mice down