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Literature summary for 2.3.1.294 extracted from

  • Vilcheze, C.; Molle, V.; Carrere-Kremer, S.; Leiba, J.; Mourey, L.; Shenai, S.; Baronian, G.; Tufariello, J.; Hartman, T.; Veyron-Churlet, R.; Trivelli, X.; Tiwari, S.; Weinrick, B.; Alland, D.; Guerardel, Y.; Jacobs Jr., W.; Kremer, L.
    Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis (2014), PLoS Pathog., 10, e1004115 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mycobacterium smegmatis Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
T334A phosphoablative mutant Mycobacterium tuberculosis
T334A/T336A phosphoablative mutant Mycobacterium tuberculosis
T334D/T336D the phosphomimetic mutant exhibits loss of acid-fast staining and is more susceptible to isoniazid, ethionamide and rifampicin compared to the wild type enzyme Mycobacterium tuberculosis
T336A phosphoablative mutant Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the enzyme at Thr334 and Thr336 profoundly decreases the condensing activity of the enzyme. Phosphorylation of the enzyme leads to increased cell wall permeability Mycobacterium tuberculosis

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase
-
 Mycobacterium tuberculosis
KasB
-
 Mycobacterium tuberculosis