show all | hide all No of entries

Information on EC 2.3.1.294 - meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II

for references in articles please use BRENDA:EC2.3.1.294
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids. Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes. The two enzymes share some sequence identity but function independently on separate sets of substrates. KasB differs from KasA (EC 2.3.1.293, meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I), by preferring longer substrates (closer to the upper limit), which also contain two double bonds.
Specify your search results
Select one or more organisms in this record: ?
The enzyme appears in viruses and cellular organisms
Synonyms
ACP specific beta-ketoacyl synthase, beta-ketoacyl AcpM synthase, beta-ketoacyl acyl carrier protein synthase II, beta-ketoacyl-ACP synthase, beta-ketoacyl-AcpM synthase, beta-ketoacyl-acyl carrier protein synthase, beta-ketoacyl-acyl carrier protein synthase B, beta-ketoacyl-acyl carrier protein synthase KasB, beta-ketoacyl-acyl-carrier protein synthase, beta-ketoacylacyl synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (Z)-hexadec-11-enoyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
show the reaction diagram
an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + a holo-[acyl-carrier protein]
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.