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Literature summary for 2.3.1.291 extracted from

  • Gosejacob, D.; Jaeger, P.S.; Vom Dorp, K.; Frejno, M.; Carstensen, A.C.; Koehnke, M.; Degen, J.; Doermann, P.; Hoch, M.
    Ceramide synthase 5 is essential to maintain C16 0-ceramide pools and contributes to the development of diet-induced obesity (2016), J. Biol. Chem., 291, 6989-7003 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine CerS5-dependent ceramide synthesis has a strong impact in white adipose tissue after high fat diet feeding Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D6K9
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Mus musculus
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lung
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 Mus musculus
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muscle
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 Mus musculus
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spleen
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 Mus musculus
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white adipose tissue
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 Mus musculus
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General Information

General Information Comment Organism
physiological function CerS5 is essential to maintain cellular C16:0 sphingolipid pools in lung, spleen, muscle, liver, and white adipose tissue. In CerS5-deficient mice, glycerophospholipid levels are not altered, while in skeletal muscle, liver, and spleen, C16:0-ceramide levels aere altered independent of feeding conditions. The loss of CerS5 is associated with reduced weight gain and improved systemic health, including maintenance of glucose homeostasis and reduced white adipose tissue inflammation after high fat diet challenge Mus musculus