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Information on EC 2.3.1.291 - sphingoid base N-palmitoyltransferase

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IUBMB Comments
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
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The enzyme appears in viruses and cellular organisms
Synonyms
CerS4, CerS5, LASS5, longevity assurance homolog 5, mammalian ceramide synthase 5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
palmitoyl-CoA + a sphingoid base = an N-(palmitoyl)-sphingoid base + CoA
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PATHWAY SOURCE
PATHWAYS
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