Literature summary for 2.3.1.291 extracted from

Choi, S.; Snider, J.M.; Olakkengil, N.; Lambert, J.M.; Anderson, A.K.; Ross-Evans, J.S.; Cowart, L.A.; Snider, A.J.
Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells (2018), FASEB J., 32, 5724-5736 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9D6K9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelium	-	Mus musculus	-
intestine	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
myristoyl-CoA + a sphingoid base	-	Mus musculus	N-(myristoyl)-sphingoid base + CoA	-	?

General Information

General Information	Comment	Organism
physiological function	inhibition of isoform Cers5 by fuminisin B1 or siRNA suppresses myristate-induced C14-ceramide generation and X-box binding protein XBP1 splicing. Increased XBP1 splicing induces the downstream expression of IL-6 in a isoforms CerS5/6-dependent manner. A myristate-enriched milk fat-based diet, but not a lard-based diet, increases C14-ceramide, XBP1 splicing, and IL-6 expression in vivo	Mus musculus

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Release 2023.1 (January 2023)