Literature summary for 2.3.1.291 extracted from

Mesicek, J.; Lee, H.; Feldman, T.; Jiang, X.; Skobeleva, A.; Berdyshev, E.V.; Haimovitz-Friedman, A.; Fuks, Z.; Kolesnick, R.
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells (2010), Cell. Signal., 22, 1300-1307 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N5B7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CerS5	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	ionizing radiation induces de novo synthesis of ceramide by specifically activating CerS isoforms 2, 5, and 6	up

General Information

General Information	Comment	Organism
physiological function	ionizing radiation induces de novo synthesis of ceramide to influence HeLa cell apoptosis by specifically activating CerS isoforms 2, 5, and 6 that generate opposing anti- and pro-apoptotic ceramides in mitochondrial membranes. Isoforms CerS5 and CerS6 each confer about 50% of the C16:0 CerS baseline synthetic activity, both are required for ionizing radiation-induced activity. Isoforms CerS2, 5, and 6 might exist as heterocomplexes in HeLa cells	Homo sapiens

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Release 2023.1 (January 2023)