Literature summary for 2.3.1.291 extracted from

Brachtendorf, S.; Wanger, R.A.; Birod, K.; Thomas, D.; Trautmann, S.; Wegner, M.S.; Fuhrmann, D.C.; Bruene, B.; Geisslinger, G.; Groesch, S.
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy (2018), Biochim. Biophys. Acta, 1863, 1214-1227 .

Search for more literature for 2.3.1.291

Application

Application	Comment	Organism
medicine	in human wild-type p53 HCT-116 colon cancer cells, treatment with oxaliplatin or 5-fluorouracil leads to a strong increase in ceramide synthase CerS5 expression and C16:0-ceramide levels, which is not seen in HCT-116 cells lacking p53 expression. The increase in CerS5 expression occurs by stabilizing CerS5 mRNA at the 3'-UTR	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N5B7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CerS5	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)