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Literature summary for 2.3.1.28 extracted from

  • Wang, J.; Liu, J.H.
    Mutations in the chloramphenicol acetyltransferase (S61G, Y105C) increase accumulated amounts and resistance in Pseudomonas aeruginosa (2004), FEMS Microbiol. Lett., 236, 197-204.
    View publication on PubMed
Search for more literature for 2.3.1.28

Protein Variants

Protein Variants Comment Organism
G61S G61S and Y105C contrtibute synergistically to the resistance phenotype of strain PAhcr1 Pseudomonas aeruginosa
G61S/Y105C G61S and Y105C contrtibute synergistically to the resistance phenotype of strain PAhcr1 Pseudomonas aeruginosa
Y105C G61S and Y105C contrtibute synergistically to the resistance phenotype of strain PAhcr1 Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.795
-
 chloramphenicol mutant enzyme G61S/Y105C Pseudomonas aeruginosa
0.797
-
 acetyl-CoA mutant enzyme G61S/Y105C Pseudomonas aeruginosa
0.798
-
 chloramphenicol wild-type enzyme Pseudomonas aeruginosa
0.8 11 chloramphenicol mutant enzyme G61S Pseudomonas aeruginosa
0.806
-
 acetyl-CoA mutant enzyme G61S Pseudomonas aeruginosa
0.809
-
 chloramphenicol mutant enzyme Y105C Pseudomonas aeruginosa
0.809
-
 acetyl-CoA mutant enzyme G61S/Y105C Pseudomonas aeruginosa
0.82
-
 acetyl-CoA mutant enzyme Y105C Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
 mutations G61S and 105C contribute synergistically to the Pahcr1 resistance phenotype
-
Pseudomonas aeruginosa Pahcr
-
 mutations G61S and 105C contribute synergistically to the Pahcr1 resistance phenotype
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + chloramphenicol
-
 Pseudomonas aeruginosa CoA + chloramphenicol 3-acetate
-
 ?
acetyl-CoA + chloramphenicol
-
 Pseudomonas aeruginosa Pahcr CoA + chloramphenicol 3-acetate
-
 ?

Synonyms

Synonyms Comment Organism
chloramphenicol acetyltransferase
-
 Pseudomonas aeruginosa