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Literature summary for 2.3.1.246 extracted from

  • Pfeifer, V.; Nicholson, G.J.; Ries, J.; Recktenwald, J.; Schefer, A.B.; Shawky, R.M.; Schröder, J.; Wohlleben, W.; Pelzer, S.
    A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (2001), J. Biol. Chem., 276, 38370-38377.
    View publication on PubMed
Search for more literature for 2.3.1.246

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Streptomyces lividans Amycolatopsis mediterranei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4 malonyl-CoA Amycolatopsis mediterranei the enzyme is involved in the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Amycolatopsis mediterranei Q939X3
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 malonyl-CoA the enzyme is involved in the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin Amycolatopsis mediterranei (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O
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 ?
4 malonyl-CoA
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 Amycolatopsis mediterranei (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O
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 ?

Synonyms

Synonyms Comment Organism
dpgA
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 Amycolatopsis mediterranei

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
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 assay at Amycolatopsis mediterranei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Amycolatopsis mediterranei

General Information

General Information Comment Organism
malfunction inactivation of dpgA results in loss of balhimycin production, and restoration is achieved by supplementation with 3,5-dihydroxyphenylacetate Amycolatopsis mediterranei
physiological function the enzyme is involved in the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin Amycolatopsis mediterranei