Application | Comment | Organism |
---|---|---|
analysis | development of LC/ESI/MS/MS-based fat absorption assay using 1-oleoyl-glycerol-d5 and U13C-triglyceride to assess the ability of MGAT2 inhibitors to inhibit fat absorption in CD1 mice by a meal tolerance test | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in HEK-293 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(benzylsulfanyl)-6-[6-[4-(4-fluorophenyl)piperazin-1-yl]pyrimidin-4-yl]-3-phenyl-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine | blocks MGAT2-mediated activity in vitro and in vivo | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q3SYC2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 2-oleoylglycerol | deuterated substrate 2-oleoylglycerol-d5 | Homo sapiens | CoA + 1-acyl-2-oleoylglycerol | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000075 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(benzylsulfanyl)-6-[6-[4-(4-fluorophenyl)piperazin-1-yl]pyrimidin-4-yl]-3-phenyl-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine |